CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor

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CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor. / Borg, NA; Wun, KS; Kjer-Nielsen, L; Wilce, MCJ; Pellicci, DG; Koh, R; Besra, Gurdyal; Bharadwaj, M; Godfrey, DI; McCluskey, J; Rossjohn, J.

In: Nature, Vol. 448, No. 7149, 20.06.2007, p. 44-49.

Research output: Contribution to journalArticle

Harvard

Borg, NA, Wun, KS, Kjer-Nielsen, L, Wilce, MCJ, Pellicci, DG, Koh, R, Besra, G, Bharadwaj, M, Godfrey, DI, McCluskey, J & Rossjohn, J 2007, 'CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor', Nature, vol. 448, no. 7149, pp. 44-49. https://doi.org/10.1038/nature05907

APA

Borg, NA., Wun, KS., Kjer-Nielsen, L., Wilce, MCJ., Pellicci, DG., Koh, R., Besra, G., Bharadwaj, M., Godfrey, DI., McCluskey, J., & Rossjohn, J. (2007). CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature, 448(7149), 44-49. https://doi.org/10.1038/nature05907

Vancouver

Borg NA, Wun KS, Kjer-Nielsen L, Wilce MCJ, Pellicci DG, Koh R et al. CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature. 2007 Jun 20;448(7149):44-49. https://doi.org/10.1038/nature05907

Author

Borg, NA ; Wun, KS ; Kjer-Nielsen, L ; Wilce, MCJ ; Pellicci, DG ; Koh, R ; Besra, Gurdyal ; Bharadwaj, M ; Godfrey, DI ; McCluskey, J ; Rossjohn, J. / CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor. In: Nature. 2007 ; Vol. 448, No. 7149. pp. 44-49.

Bibtex

@article{66899bf45cb54d61ba6650b998a05056,
title = "CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor",
abstract = "The CD1 family is a large cluster of non-polymorphic, major histocompatibility complex (MHC) class-I-like molecules that bind distinct lipid-based antigens that are recognized by T cells. The most studied group of T cells that interact with lipid antigens are natural killer T (NKT) cells, which characteristically express a semi-invariant T-cell receptor ( NKT TCR) that specifically recognizes the CD1 family member, CD1d. NKT-cell-mediated recognition of the CD1d - antigen complex has been implicated in microbial immunity, tumour immunity, autoimmunity and allergy. Here we describe the structure of a human NKT TCR in complex with CD1d bound to the potent NKT-cell agonist alpha-galactosylceramide, the archetypal CD1d-restricted glycolipid. In contrast to T-cell receptor - peptide- antigen - MHC complexes, the NKT TCR docked parallel to, and at the extreme end of the CD1d-binding cleft, which enables a lock-and-key type interaction with the lipid antigen. The structure provides a basis for the interaction between the highly conserved NKT TCR alpha-chain and the CD1d - antigen complex that is typified in innate immunity, and also indicates how variability of the NKT TCR beta-chain can impact on recognition of other CD1d - antigen complexes. These findings provide direct insight into how a T-cell receptor recognizes a lipid-antigen-presenting molecule of the immune system.",
author = "NA Borg and KS Wun and L Kjer-Nielsen and MCJ Wilce and DG Pellicci and R Koh and Gurdyal Besra and M Bharadwaj and DI Godfrey and J McCluskey and J Rossjohn",
year = "2007",
month = jun,
day = "20",
doi = "10.1038/nature05907",
language = "English",
volume = "448",
pages = "44--49",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7149",

}

RIS

TY - JOUR

T1 - CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor

AU - Borg, NA

AU - Wun, KS

AU - Kjer-Nielsen, L

AU - Wilce, MCJ

AU - Pellicci, DG

AU - Koh, R

AU - Besra, Gurdyal

AU - Bharadwaj, M

AU - Godfrey, DI

AU - McCluskey, J

AU - Rossjohn, J

PY - 2007/6/20

Y1 - 2007/6/20

N2 - The CD1 family is a large cluster of non-polymorphic, major histocompatibility complex (MHC) class-I-like molecules that bind distinct lipid-based antigens that are recognized by T cells. The most studied group of T cells that interact with lipid antigens are natural killer T (NKT) cells, which characteristically express a semi-invariant T-cell receptor ( NKT TCR) that specifically recognizes the CD1 family member, CD1d. NKT-cell-mediated recognition of the CD1d - antigen complex has been implicated in microbial immunity, tumour immunity, autoimmunity and allergy. Here we describe the structure of a human NKT TCR in complex with CD1d bound to the potent NKT-cell agonist alpha-galactosylceramide, the archetypal CD1d-restricted glycolipid. In contrast to T-cell receptor - peptide- antigen - MHC complexes, the NKT TCR docked parallel to, and at the extreme end of the CD1d-binding cleft, which enables a lock-and-key type interaction with the lipid antigen. The structure provides a basis for the interaction between the highly conserved NKT TCR alpha-chain and the CD1d - antigen complex that is typified in innate immunity, and also indicates how variability of the NKT TCR beta-chain can impact on recognition of other CD1d - antigen complexes. These findings provide direct insight into how a T-cell receptor recognizes a lipid-antigen-presenting molecule of the immune system.

AB - The CD1 family is a large cluster of non-polymorphic, major histocompatibility complex (MHC) class-I-like molecules that bind distinct lipid-based antigens that are recognized by T cells. The most studied group of T cells that interact with lipid antigens are natural killer T (NKT) cells, which characteristically express a semi-invariant T-cell receptor ( NKT TCR) that specifically recognizes the CD1 family member, CD1d. NKT-cell-mediated recognition of the CD1d - antigen complex has been implicated in microbial immunity, tumour immunity, autoimmunity and allergy. Here we describe the structure of a human NKT TCR in complex with CD1d bound to the potent NKT-cell agonist alpha-galactosylceramide, the archetypal CD1d-restricted glycolipid. In contrast to T-cell receptor - peptide- antigen - MHC complexes, the NKT TCR docked parallel to, and at the extreme end of the CD1d-binding cleft, which enables a lock-and-key type interaction with the lipid antigen. The structure provides a basis for the interaction between the highly conserved NKT TCR alpha-chain and the CD1d - antigen complex that is typified in innate immunity, and also indicates how variability of the NKT TCR beta-chain can impact on recognition of other CD1d - antigen complexes. These findings provide direct insight into how a T-cell receptor recognizes a lipid-antigen-presenting molecule of the immune system.

U2 - 10.1038/nature05907

DO - 10.1038/nature05907

M3 - Article

C2 - 17581592

VL - 448

SP - 44

EP - 49

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7149

ER -