CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin

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CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin. / Flores-Langarica, A; Müller Luda, K; Persson, E K; Cook, C N; Bobat, S; Marshall, J L; Dahlgren, M W; Hägerbrand, K; Toellner, K M; Goodall, M D; Withers, David; Henderson, I R; Johansson Lindbom, B; Agace, W W; Cunningham, Adam.

In: Mucosal immunology, Vol. 11, No. 3, 01.05.2018, p. 681-692.

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Flores-Langarica, A ; Müller Luda, K ; Persson, E K ; Cook, C N ; Bobat, S ; Marshall, J L ; Dahlgren, M W ; Hägerbrand, K ; Toellner, K M ; Goodall, M D ; Withers, David ; Henderson, I R ; Johansson Lindbom, B ; Agace, W W ; Cunningham, Adam. / CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin. In: Mucosal immunology. 2018 ; Vol. 11, No. 3. pp. 681-692.

Bibtex

@article{14c1ce79882f4538afcce53e6d368fb4,
title = "CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin",
abstract = "Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103+CD11b+ (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103+CD11b- (SP) are not required for these responses. The lack of this response correlated with a complete absence of sFliC-specific plasma cells in the MLN, small intestinal lamina propria, and surprisingly also the bone marrow (BM). Many sFliC-specific plasma cells accumulating in the BM of immunized wild-type mice expressed α4β7+, suggesting a mucosal origin. Collectively, these results suggest that mucosal DP cDC contribute to the generation of the sFliC-specific plasma cell pool in the BM and thus serve as a bridge linking the mucosal and systemic immune system.",
author = "A Flores-Langarica and {M{\"u}ller Luda}, K and Persson, {E K} and Cook, {C N} and S Bobat and Marshall, {J L} and Dahlgren, {M W} and K H{\"a}gerbrand and Toellner, {K M} and Goodall, {M D} and David Withers and Henderson, {I R} and {Johansson Lindbom}, B and Agace, {W W} and Adam Cunningham",
year = "2018",
month = may,
day = "1",
doi = "10.1038/mi.2017.105",
language = "English",
volume = "11",
pages = "681--692",
journal = "Mucosal immunology",
issn = "1933-0219",
publisher = "Nature Publishing Group",
number = "3",

}

RIS

TY - JOUR

T1 - CD103+CD11b+ mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin

AU - Flores-Langarica, A

AU - Müller Luda, K

AU - Persson, E K

AU - Cook, C N

AU - Bobat, S

AU - Marshall, J L

AU - Dahlgren, M W

AU - Hägerbrand, K

AU - Toellner, K M

AU - Goodall, M D

AU - Withers, David

AU - Henderson, I R

AU - Johansson Lindbom, B

AU - Agace, W W

AU - Cunningham, Adam

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103+CD11b+ (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103+CD11b- (SP) are not required for these responses. The lack of this response correlated with a complete absence of sFliC-specific plasma cells in the MLN, small intestinal lamina propria, and surprisingly also the bone marrow (BM). Many sFliC-specific plasma cells accumulating in the BM of immunized wild-type mice expressed α4β7+, suggesting a mucosal origin. Collectively, these results suggest that mucosal DP cDC contribute to the generation of the sFliC-specific plasma cell pool in the BM and thus serve as a bridge linking the mucosal and systemic immune system.

AB - Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103+CD11b+ (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic immunization with soluble flagellin (sFliC). In contrast, IRF8-dependent CD103+CD11b- (SP) are not required for these responses. The lack of this response correlated with a complete absence of sFliC-specific plasma cells in the MLN, small intestinal lamina propria, and surprisingly also the bone marrow (BM). Many sFliC-specific plasma cells accumulating in the BM of immunized wild-type mice expressed α4β7+, suggesting a mucosal origin. Collectively, these results suggest that mucosal DP cDC contribute to the generation of the sFliC-specific plasma cell pool in the BM and thus serve as a bridge linking the mucosal and systemic immune system.

U2 - 10.1038/mi.2017.105

DO - 10.1038/mi.2017.105

M3 - Article

C2 - 29346347

VL - 11

SP - 681

EP - 692

JO - Mucosal immunology

JF - Mucosal immunology

SN - 1933-0219

IS - 3

ER -