CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes

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CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes. / Mackley, Emma C.; Houston, Stephanie; Marriott, Clare L.; Halford, Emily E.; Lucas, Beth; Cerovic, Vuk; Filbey, Kara J.; Maizels, Rick M.; Hepworth, Matthew R.; Sonnenberg, Gregory F.; Milling, Simon; Withers, David R.

In: Nature Communications, Vol. 6, 5862, 09.01.2015.

Research output: Contribution to journalArticlepeer-review

Harvard

Mackley, EC, Houston, S, Marriott, CL, Halford, EE, Lucas, B, Cerovic, V, Filbey, KJ, Maizels, RM, Hepworth, MR, Sonnenberg, GF, Milling, S & Withers, DR 2015, 'CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes', Nature Communications, vol. 6, 5862. https://doi.org/10.1038/ncomms6862

APA

Mackley, E. C., Houston, S., Marriott, C. L., Halford, E. E., Lucas, B., Cerovic, V., Filbey, K. J., Maizels, R. M., Hepworth, M. R., Sonnenberg, G. F., Milling, S., & Withers, D. R. (2015). CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes. Nature Communications, 6, [5862]. https://doi.org/10.1038/ncomms6862

Vancouver

Author

Mackley, Emma C. ; Houston, Stephanie ; Marriott, Clare L. ; Halford, Emily E. ; Lucas, Beth ; Cerovic, Vuk ; Filbey, Kara J. ; Maizels, Rick M. ; Hepworth, Matthew R. ; Sonnenberg, Gregory F. ; Milling, Simon ; Withers, David R. / CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes. In: Nature Communications. 2015 ; Vol. 6.

Bibtex

@article{35d1d43678fb4e78a61b746341b361ce,
title = "CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes",
abstract = "Presentation of peptide:MHCII by ​RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of ​CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was ​CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.",
keywords = "Biological sciences, Immunology",
author = "Mackley, {Emma C.} and Stephanie Houston and Marriott, {Clare L.} and Halford, {Emily E.} and Beth Lucas and Vuk Cerovic and Filbey, {Kara J.} and Maizels, {Rick M.} and Hepworth, {Matthew R.} and Sonnenberg, {Gregory F.} and Simon Milling and Withers, {David R.}",
year = "2015",
month = jan,
day = "9",
doi = "10.1038/ncomms6862",
language = "English",
volume = "6",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes

AU - Mackley, Emma C.

AU - Houston, Stephanie

AU - Marriott, Clare L.

AU - Halford, Emily E.

AU - Lucas, Beth

AU - Cerovic, Vuk

AU - Filbey, Kara J.

AU - Maizels, Rick M.

AU - Hepworth, Matthew R.

AU - Sonnenberg, Gregory F.

AU - Milling, Simon

AU - Withers, David R.

PY - 2015/1/9

Y1 - 2015/1/9

N2 - Presentation of peptide:MHCII by ​RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of ​CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was ​CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.

AB - Presentation of peptide:MHCII by ​RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of ​CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was ​CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.

KW - Biological sciences

KW - Immunology

UR - https://www.nature.com/articles/ncomms11186

U2 - 10.1038/ncomms6862

DO - 10.1038/ncomms6862

M3 - Article

C2 - 25575242

VL - 6

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 5862

ER -