CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes

Research output: Contribution to journalArticle

Authors

  • Emma C. Mackley
  • Stephanie Houston
  • Clare L. Marriott
  • Emily E. Halford
  • Vuk Cerovic
  • Kara J. Filbey
  • Rick M. Maizels
  • Matthew R. Hepworth
  • Gregory F. Sonnenberg
  • Simon Milling

Colleges, School and Institutes

Abstract

Presentation of peptide:MHCII by ​RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of ​CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was ​CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.

Details

Original languageEnglish
Article number5862
JournalNature Communications
Volume6
Publication statusPublished - 9 Jan 2015

Keywords

  • Biological sciences, Immunology