Caveolin-1 single-nucleotide polymorphism and arterial stiffness in non-dialysis chronic kidney disease

Research output: Contribution to journalArticle

Authors

  • Sourabh Chand
  • Nicola C Edwards
  • Colin D Chue
  • Mark Jesky
  • Stephanie Stringer
  • And 8 others
  • Matthew J Simmonds
  • Claire E Duff
  • Paul Cockwell
  • Lorraine Harper
  • Richard P Steeds
  • Jonathan N Townend
  • Charles J Ferro
  • Richard Borrows

External organisations

  • Department of Renal Medicine, Queen Elizabeth Hospital Birmingham, Birmingham, UK Centre for Translational Inflammation Research, University of Birmingham, Birmingham, UK.
  • Department of Cardiology, Queen Elizabeth Hospital, Birmingham
  • Oxford Centre for Diabetes, Endocrinology, Diabetes and Metabolism, University of Oxford, Oxford

Abstract

BACKGROUND: Arteriosclerosis is an independent predictor of increased cardiovascular mortality in chronic kidney disease (CKD). Histologically it is characterized by hypertrophy and fibrosis of the arterial media wall leading to increased arterial stiffness and end-organ damage. Caveolin-1 acts as an intracellular signalling pathway chaperone in human fibrotic and vascular diseases. The purpose of this study was to assess the association between caveolin-1 (CAV1) single-nucleotide polymorphism (SNP) rs4730751 and arterial stiffness as measured by arterial pulse wave velocity (PWV) in an early-stage CKD cohort and in a cohort with more severe CKD.

METHODS: Two prospectively maintained patient cohorts with non-dialysis CKD were studied: 144 patients in the Chronic Renal Impairment in Birmingham (CRIB) cohort and 147 patients in the Renal Impairment in Secondary Care (RIISC) cohort, with matched exclusion criteria and DNA sampling availability. At entry to each cohort database, each patient's initial arterial PWV was measured, as well as their anthropomorphic and biochemical data. CAV1 rs4730751 SNP genotyping was performed using Taqman technology.

RESULTS: The CAV1 rs4730751 SNP CC genotype was associated with lower arterial PWV in both CRIB early stage CKD patients [8.1 versus 8.6 m/s; coefficient -0.780 (-1.412, -0.149); P = 0.016] and RIISC more advanced stage CKD patients [8.7 versus 9.4 m/s; coefficient -0.695 (-1.288, -0.102); P = 0.022]; these relationships held following adjustment for other important confounders.

CONCLUSIONS: This replicated study suggests potential utility of the studied CAV1 SNP as a genetic biomarker in CKD and a role for CAV1 in the development of arteriosclerosis in this setting. Further studies are warranted to further explore the basic science driving these clinical observations.

Details

Original languageEnglish
Pages (from-to)1140-1144
Number of pages5
JournalNephrology, Dialysis, Transplantation
Volume31
Issue number7
Early online date3 Oct 2015
Publication statusPublished - Jul 2016

Keywords

  • arterial stiffness , caveolin-1 , chronic kidney disease , pulse wave velocity , single-nucleotide polymorphism