Causal Models of Clinically Significant Behaviors in Angelman, Cornelia de Lange, Prader-Willi and Smith-Magenis Syndromes

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Standard

Causal Models of Clinically Significant Behaviors in Angelman, Cornelia de Lange, Prader-Willi and Smith-Magenis Syndromes. / Oliver, C.; Adams, D.; Allen, D.; Bull, L.; Heald, M.; Moss, J.; Wilde, L.; Woodcock, K.

International Review of Research in Developmental Disabilities: Challenging Behavior. ed. / Richard Hastings; Johannes Rojahn. Vol. 44 Academic Press (Elsevier), 2013. p. 167-211 (International Review of Research in Developmental Disabilities; Vol. 44).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Harvard

Oliver, C, Adams, D, Allen, D, Bull, L, Heald, M, Moss, J, Wilde, L & Woodcock, K 2013, Causal Models of Clinically Significant Behaviors in Angelman, Cornelia de Lange, Prader-Willi and Smith-Magenis Syndromes. in R Hastings & J Rojahn (eds), International Review of Research in Developmental Disabilities: Challenging Behavior. vol. 44, International Review of Research in Developmental Disabilities, vol. 44, Academic Press (Elsevier), pp. 167-211. https://doi.org/10.1016/B978-0-12-401662-0.00006-3

APA

Oliver, C., Adams, D., Allen, D., Bull, L., Heald, M., Moss, J., Wilde, L., & Woodcock, K. (2013). Causal Models of Clinically Significant Behaviors in Angelman, Cornelia de Lange, Prader-Willi and Smith-Magenis Syndromes. In R. Hastings, & J. Rojahn (Eds.), International Review of Research in Developmental Disabilities: Challenging Behavior (Vol. 44, pp. 167-211). (International Review of Research in Developmental Disabilities; Vol. 44). Academic Press (Elsevier). https://doi.org/10.1016/B978-0-12-401662-0.00006-3

Vancouver

Oliver C, Adams D, Allen D, Bull L, Heald M, Moss J et al. Causal Models of Clinically Significant Behaviors in Angelman, Cornelia de Lange, Prader-Willi and Smith-Magenis Syndromes. In Hastings R, Rojahn J, editors, International Review of Research in Developmental Disabilities: Challenging Behavior. Vol. 44. Academic Press (Elsevier). 2013. p. 167-211. (International Review of Research in Developmental Disabilities). https://doi.org/10.1016/B978-0-12-401662-0.00006-3

Author

Oliver, C. ; Adams, D. ; Allen, D. ; Bull, L. ; Heald, M. ; Moss, J. ; Wilde, L. ; Woodcock, K. / Causal Models of Clinically Significant Behaviors in Angelman, Cornelia de Lange, Prader-Willi and Smith-Magenis Syndromes. International Review of Research in Developmental Disabilities: Challenging Behavior. editor / Richard Hastings ; Johannes Rojahn. Vol. 44 Academic Press (Elsevier), 2013. pp. 167-211 (International Review of Research in Developmental Disabilities).

Bibtex

@inbook{29804767234541c0b9b6441dcbc5a810,
title = "Causal Models of Clinically Significant Behaviors in Angelman, Cornelia de Lange, Prader-Willi and Smith-Magenis Syndromes",
abstract = "The operant learning theory account of behaviors of clinical significance in people with intellectual disability (ID) has dominated the field for nearly 50 years. However, in the last two decades, there has been a substantial increase in published research that describes the behavioral phenotypes of genetic disorders and shows that behaviors such as self-injury and aggression are more common in some syndromes than might be expected given group characteristics. These cross-syndrome differences in prevalence warrant explanation, not least because this observation challenges an exclusively operant learning theory account. To explore this possible conflict between theoretical account and empirical observation, we describe the genetic cause and physical, social, cognitive and behavioral phenotypes of four disorders associated with ID (Angleman, Cornelia de Lange, Prader-Willi and Smith-Magenis syndromes) and focus on the behaviors of clinical significance in each syndrome. For each syndrome we then describe a model of the interactions between physical characteristics, cognitive and motivational endophenotypes and environmental factors (including operant. reinforcement) to account for the resultant behavioral phenotype. In each syndrome it is possible to identify pathways from gene to physical phenotype to cognitive or motivational endophenotype to behavior to environment and back to behavior. We identify the implications of these models for responsive and early intervention and the challenges for research in this area. We identify a pressing need for meaningful dialog between different disciplines to construct better informed models that can incorporate all relevant and robust empirical evidence. {\textcopyright} 2013 Elsevier Inc.",
keywords = "Aggression, Behavioral phenotype, Impulsivity, Intellectual disability, Self-injury, Sleep, Temper outbursts",
author = "C. Oliver and D. Adams and D. Allen and L. Bull and M. Heald and J. Moss and L. Wilde and K. Woodcock",
year = "2013",
doi = "10.1016/B978-0-12-401662-0.00006-3",
language = "English",
isbn = "9780124016620",
volume = "44",
series = "International Review of Research in Developmental Disabilities",
publisher = "Academic Press (Elsevier)",
pages = "167--211",
editor = "Richard Hastings and Johannes Rojahn",
booktitle = "International Review of Research in Developmental Disabilities",

}

RIS

TY - CHAP

T1 - Causal Models of Clinically Significant Behaviors in Angelman, Cornelia de Lange, Prader-Willi and Smith-Magenis Syndromes

AU - Oliver, C.

AU - Adams, D.

AU - Allen, D.

AU - Bull, L.

AU - Heald, M.

AU - Moss, J.

AU - Wilde, L.

AU - Woodcock, K.

PY - 2013

Y1 - 2013

N2 - The operant learning theory account of behaviors of clinical significance in people with intellectual disability (ID) has dominated the field for nearly 50 years. However, in the last two decades, there has been a substantial increase in published research that describes the behavioral phenotypes of genetic disorders and shows that behaviors such as self-injury and aggression are more common in some syndromes than might be expected given group characteristics. These cross-syndrome differences in prevalence warrant explanation, not least because this observation challenges an exclusively operant learning theory account. To explore this possible conflict between theoretical account and empirical observation, we describe the genetic cause and physical, social, cognitive and behavioral phenotypes of four disorders associated with ID (Angleman, Cornelia de Lange, Prader-Willi and Smith-Magenis syndromes) and focus on the behaviors of clinical significance in each syndrome. For each syndrome we then describe a model of the interactions between physical characteristics, cognitive and motivational endophenotypes and environmental factors (including operant. reinforcement) to account for the resultant behavioral phenotype. In each syndrome it is possible to identify pathways from gene to physical phenotype to cognitive or motivational endophenotype to behavior to environment and back to behavior. We identify the implications of these models for responsive and early intervention and the challenges for research in this area. We identify a pressing need for meaningful dialog between different disciplines to construct better informed models that can incorporate all relevant and robust empirical evidence. © 2013 Elsevier Inc.

AB - The operant learning theory account of behaviors of clinical significance in people with intellectual disability (ID) has dominated the field for nearly 50 years. However, in the last two decades, there has been a substantial increase in published research that describes the behavioral phenotypes of genetic disorders and shows that behaviors such as self-injury and aggression are more common in some syndromes than might be expected given group characteristics. These cross-syndrome differences in prevalence warrant explanation, not least because this observation challenges an exclusively operant learning theory account. To explore this possible conflict between theoretical account and empirical observation, we describe the genetic cause and physical, social, cognitive and behavioral phenotypes of four disorders associated with ID (Angleman, Cornelia de Lange, Prader-Willi and Smith-Magenis syndromes) and focus on the behaviors of clinical significance in each syndrome. For each syndrome we then describe a model of the interactions between physical characteristics, cognitive and motivational endophenotypes and environmental factors (including operant. reinforcement) to account for the resultant behavioral phenotype. In each syndrome it is possible to identify pathways from gene to physical phenotype to cognitive or motivational endophenotype to behavior to environment and back to behavior. We identify the implications of these models for responsive and early intervention and the challenges for research in this area. We identify a pressing need for meaningful dialog between different disciplines to construct better informed models that can incorporate all relevant and robust empirical evidence. © 2013 Elsevier Inc.

KW - Aggression

KW - Behavioral phenotype

KW - Impulsivity

KW - Intellectual disability

KW - Self-injury

KW - Sleep

KW - Temper outbursts

U2 - 10.1016/B978-0-12-401662-0.00006-3

DO - 10.1016/B978-0-12-401662-0.00006-3

M3 - Chapter (peer-reviewed)

SN - 9780124016620

VL - 44

T3 - International Review of Research in Developmental Disabilities

SP - 167

EP - 211

BT - International Review of Research in Developmental Disabilities

A2 - Hastings, Richard

A2 - Rojahn, Johannes

PB - Academic Press (Elsevier)

ER -