Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action

Research output: Contribution to journalArticle

Authors

  • Jennifer Swart
  • Monja Frobose
  • Dirk Geurts
  • Michael Frank
  • Roshan Cools
  • Hanneke E M Den Ouden

Colleges, School and Institutes

External organisations

  • FC Donders Ctr Cognit Neuroimaging
  • Brown University
  • Radboud University Medical Centre

Abstract

Catecholamines modulate the impact of motivational cues on action. Such motivational biases have been proposed to reflect cue-based, ‘Pavlovian’ effects. Here, we assess whether motivational biases may also arise from asymmetrical instrumental learning of active and passive responses following reward and punishment outcomes. We present a novel paradigm, allowing us to disentangle the impact of reward and punishment on instrumental learning from Pavlovian response biasing. Computational analyses showed that motivational biases reflect both Pavlovian and instrumental effects: reward and punishment cues promoted generalized (in)action in a Pavlovian manner, whereas outcomes enhanced instrumental (un)learning of chosen actions. These cue- and outcome-based biases were altered independently by the catecholamine enhancer melthylphenidate. Methylphenidate’s effect varied across individuals with a putative proxy of baseline dopamine synthesis capacity, working memory span. Our study uncovers two distinct mechanisms by which motivation impacts behaviour, and helps refine current models of catecholaminergic modulation of motivated action.

Details

Original languageEnglish
Article numbere22169
JournalElife
Volume6
Early online date26 Apr 2017
Publication statusPublished - 15 May 2017

Keywords

  • Dopamine, Learning, Action, reward