CASA: tracking the past and plotting the future

Research output: Contribution to journalReview article

Colleges, School and Institutes

External organisations

  • Centre for Human Reproductive Science, Birmingham Women’s and Children’s NHS Foundation Trust
  • Centre for Human Reproductive Science, Birmingham Women’s and Children’s NHS Foundation Trust
  • Centre for Human Reproductive Science, Birmingham Women’s and Children’s NHS Foundation Trust

Abstract

The human semen sample carries a wealth of information of varying degrees of accessibility ranging from the traditional visual measures of count and motility to those that need a more computational approach, such as tracking the flagellar waveform. Although computer-aided sperm analysis (CASA) options are becoming more widespread, the gold standard for clinical semen analysis requires trained laboratory staff. In this review we characterise the key attitudes towards the use of CASA and set out areas in which CASA should, and should not, be used and improved. We provide an overview of the current CASA landscape, discussing clinical uses as well as potential areas for the clinical translation of existing research technologies. Finally, we discuss where we see potential for the future of CASA, and how the integration of mathematical modelling and new technologies, such as automated flagellar tracking, may open new doors in clinical semen analysis

Details

Original languageEnglish
Pages (from-to)867-874
Number of pages8
JournalReproduction Fertility and Development
Volume30
Issue number6
Publication statusPublished - 29 May 2018

Keywords

  • clinical diagnostics, flagellar analysis, glyphs, image analysis, machine learning, mathematical modelling, sperm, viscosity