Cardiovascular risk factors in women with primary Sjögren's syndrome: United Kingdom primary Sjögren's syndrome registry results

Research output: Contribution to journalArticlepeer-review


  • T. E. Toms
  • S. Mitchell
  • S. Bowman
  • P. Nightingale
  • E. J. Price
  • B. Griffiths
  • J. Hunter
  • M. Gupta
  • M. Bombardieri
  • N. Sutcliffe
  • C. Pitzalis
  • C. Pease
  • J. Andrews
  • P. Emery
  • M. Regan
  • I. Giles
  • D. Isenberg
  • R. Moots
  • K. S. Collins
  • W. F. Ng
  • G. D. Kitas

External organisations

  • Queen Elizabeth Hospital Birmingham
  • Dudley Group of Hospitals NHS Trust
  • Newcastle University
  • Great Western Hospitals NHS Foundation Trust; Swindon UK
  • Gartnavel General Hospital; Glasgow UK
  • Barts and The London NHS Trust
  • Derbyshire Royal Infirmary NHS Foundation Trust; Derby UK
  • University College London Hospitals NHS Foundation Trust
  • Aintree University Hospitals NHS Foundation Trust
  • Dudley Group of Hospitals NHS Trust, Dudley, UK, and Manchester University; Manchester UK


Objective. To determine the prevalence of traditional cardiovascular risk factors using established definitions in a large cohort of clinically well-characterized primary Sjögren’s syndrome (SS) patients and to compare them to healthy controls.

Methods. Data on cardiovascular risk factors in primary SS patients and controls were collected prospectively using a standardized pro forma. Cardiovascular risk factors were defined according to established definitions. The prevalence of cardiovascular risk factors in the primary SS group was determined and compared to that in the control group.

Results. Primary SS patients had a higher prevalence of hypertension (28 –50% versus 15.5–25.6%; P < 0.01) and hypertriglyceridemia (21% versus 9.5%; P  0.002) than age- and sex-matched healthy controls. Furthermore, a significant percentage (56%) of hypertensive patients expected to be on antihypertensive treatment according to best practice was not receiving it.

Conclusion. Primary SS patients are more than 2 times more likely to experience hypertension and hypertriglyceridemia than age and sex-matched healthy controls. Additionally, hypertension is underdiagnosed and suboptimally treated in primary SS.


Original languageEnglish
Pages (from-to)757-764
JournalArthritis Care & Research
Issue number5
Early online date31 Oct 2013
Publication statusPublished - 1 May 2014