Cardiovascular activity and the antibody response to vaccination.

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@article{f8199296081c471cbd1c2fce93bf1e49,
title = "Cardiovascular activity and the antibody response to vaccination.",
abstract = "OBJECTIVE: To examine the relationship between cardiovascular activity in response to acute psychological stress and the antibody response to vaccination. METHODS: Fifty-seven healthy participants were vaccinated with the trivalent influenza vaccine and meningococcal A+C polysaccharides. Antibody levels were measured at baseline and 5-weeks post-vaccination. Cardiovascular activity was measured at rest, during, and following a mental arithmetic stress task in 54 participants. RESULTS: Participants demonstrating a fourfold increase in antibody titre to the A/Panama and B/Shangdong influenza strains and to meningococcal A showed greater blood pressure reactions toward the end of the acute stress task. In addition, there was some evidence of delayed diastolic blood pressure recovery in those who were responders to A/Panama and B/Shangdong influenza strains. CONCLUSION: The present results suggest that heightened cardiovascular reactivity to stress and delayed recovery may not necessarily be detrimental to all aspects of health and may be associated with an enhanced immune response to antigen challenge.",
keywords = "Meningococcal A plus C vaccination, Influenza vaccination, Cardiovascular reactivity, Acute stress",
author = "Anna Phillips and Douglas Carroll and Victoria Burns and Mark Drayson",
year = "2009",
month = jul,
day = "1",
doi = "10.1016/j.jpsychores.2008.12.002",
language = "English",
volume = "67",
pages = "37--43",
journal = "Journal of Psychosomatic Research",
issn = "0022-3999",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Cardiovascular activity and the antibody response to vaccination.

AU - Phillips, Anna

AU - Carroll, Douglas

AU - Burns, Victoria

AU - Drayson, Mark

PY - 2009/7/1

Y1 - 2009/7/1

N2 - OBJECTIVE: To examine the relationship between cardiovascular activity in response to acute psychological stress and the antibody response to vaccination. METHODS: Fifty-seven healthy participants were vaccinated with the trivalent influenza vaccine and meningococcal A+C polysaccharides. Antibody levels were measured at baseline and 5-weeks post-vaccination. Cardiovascular activity was measured at rest, during, and following a mental arithmetic stress task in 54 participants. RESULTS: Participants demonstrating a fourfold increase in antibody titre to the A/Panama and B/Shangdong influenza strains and to meningococcal A showed greater blood pressure reactions toward the end of the acute stress task. In addition, there was some evidence of delayed diastolic blood pressure recovery in those who were responders to A/Panama and B/Shangdong influenza strains. CONCLUSION: The present results suggest that heightened cardiovascular reactivity to stress and delayed recovery may not necessarily be detrimental to all aspects of health and may be associated with an enhanced immune response to antigen challenge.

AB - OBJECTIVE: To examine the relationship between cardiovascular activity in response to acute psychological stress and the antibody response to vaccination. METHODS: Fifty-seven healthy participants were vaccinated with the trivalent influenza vaccine and meningococcal A+C polysaccharides. Antibody levels were measured at baseline and 5-weeks post-vaccination. Cardiovascular activity was measured at rest, during, and following a mental arithmetic stress task in 54 participants. RESULTS: Participants demonstrating a fourfold increase in antibody titre to the A/Panama and B/Shangdong influenza strains and to meningococcal A showed greater blood pressure reactions toward the end of the acute stress task. In addition, there was some evidence of delayed diastolic blood pressure recovery in those who were responders to A/Panama and B/Shangdong influenza strains. CONCLUSION: The present results suggest that heightened cardiovascular reactivity to stress and delayed recovery may not necessarily be detrimental to all aspects of health and may be associated with an enhanced immune response to antigen challenge.

KW - Meningococcal A plus C vaccination

KW - Influenza vaccination

KW - Cardiovascular reactivity

KW - Acute stress

U2 - 10.1016/j.jpsychores.2008.12.002

DO - 10.1016/j.jpsychores.2008.12.002

M3 - Article

C2 - 19539817

VL - 67

SP - 37

EP - 43

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

SN - 0022-3999

IS - 1

ER -