Cardiac optical mapping – state-of-the-art and future challenges

Research output: Contribution to journalShort surveypeer-review

External organisations

  • Department of Experimental Psychology
  • University Hospitals Birmingham NHS Trust

Abstract

Cardiac optical mapping utilises fluorescent dyes to directly image the electrical function of the heart at a high spatio-temporal resolution which far exceeds electrode techniques. It has therefore become an invaluable tool in cardiac electrophysiological research to map the propagation of heterogeneous electrical signals across the myocardium. In this review, we introduce the principles behind cardiac optical mapping and discuss some of the challenges and state of the art in the field. Key advancements discussed include newly developed fluorescent indicators, tools for the analysis of complex datasets, panoramic imaging systems and technical and computational approaches to realise optical mapping in freely beating hearts.

Details

Original languageEnglish
Article number105804
JournalInternational Journal of Biochemistry and Cell Biology
Volume126
Early online date15 Jul 2020
Publication statusPublished - Sep 2020

Keywords

  • Action potential, Arrhythmia, Calcium transient, Cardiac optical mapping, Electrophysiology, Fluorescent imaging

ASJC Scopus subject areas