Abstract
Cardiac hypertrophy is characterised by an imbalance between lipid uptake and fatty acid beta-oxidation leading to an accumulation of lipids, particularly triacylglycerol (TAG). It is unclear whether uptake mechanisms such as lipoprotein lipase (LPL) can be attenuated to diminish this uptake. Rats were cold acclimated to induce cardiac hypertrophy and increase cardiac LPL Lipid uptake and metabolism were altered by feeding a 'Western-style' high fat diet (WSD) or feeding oxfenicine (2 g/L) in the drinking water. Diastolic stiffness (increased volume change/unit pressure change) was induced in hypertrophied hearts for rats fed WSD (P
Original language | English |
---|---|
Pages (from-to) | 627-636 |
Number of pages | 10 |
Journal | Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids |
Volume | 1821 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2012 |
Keywords
- Lipoprotein lipase
- Very-low-density lipoprotein
- Cardiac hypertrophy
- ANGPTL4