Cannabis use and hypomania in young people: a prospective analysis

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Cannabis use and hypomania in young people : a prospective analysis. / Marwaha, Steven; Winsper, Catherine; Bebbington, Paul; Smith, Daniel.

In: Schizophrenia bulletin, Vol. 44, No. 6, 11.2018, p. 1267-1274.

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Marwaha, Steven ; Winsper, Catherine ; Bebbington, Paul ; Smith, Daniel. / Cannabis use and hypomania in young people : a prospective analysis. In: Schizophrenia bulletin. 2018 ; Vol. 44, No. 6. pp. 1267-1274.

Bibtex

@article{6caec32622444b37a42b240b1d970c6e,
title = "Cannabis use and hypomania in young people: a prospective analysis",
abstract = "Background: Cannabis use in young people is common and associated with psychiatric disorders. However, the prospective link between cannabis use and bipolar disorder symptoms has rarely been investigated. The study hypothesis was that adolescent cannabis use is associated with hypomania in early adulthood via several potential etiological pathways.Methods: Data were used from the Avon Longitudinal Study of Parents and Children, a UK birth cohort study. The prospective link between cannabis use at age 17 and hypomania at age 22-23 years was tested using regression analysis, adjusted for gender, early environmental risk factors, alcohol and drug use, and depression and psychotic symptoms at age 18 years. Path analysis examined direct and indirect effects of the link and whether gender, childhood family adversity, or childhood abuse are associated with hypomania via an increased risk of cannabis use.Results: Data were available on 3370 participants. Cannabis use at least 2-3 times weekly was associated with later hypomania (OR = 2.21, 95% CI = 1.49-3.28) after adjustment. There was a dose-response relationship (any use vs weekly). Cannabis use mediated the association of both childhood sexual abuse and hypomania, and male gender and hypomania. The cannabis use-hypomania link was not mediated by depression or psychotic symptoms.Conclusions: Adolescent cannabis use may be an independent risk factor for future hypomania, and the nature of the association suggests a potential causal link. Cannabis use mediates the link between childhood abuse and future hypomania. As such it might be a useful target for indicated prevention of hypomania.",
keywords = "cannabis, mania, psychopathology, birth cohort, child abuse, ALSPAC, adolescents",
author = "Steven Marwaha and Catherine Winsper and Paul Bebbington and Daniel Smith",
year = "2018",
month = nov,
doi = "10.1093/schbul/sbx158",
language = "English",
volume = "44",
pages = "1267--1274",
journal = "Schizophrenia bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Cannabis use and hypomania in young people

T2 - a prospective analysis

AU - Marwaha, Steven

AU - Winsper, Catherine

AU - Bebbington, Paul

AU - Smith, Daniel

PY - 2018/11

Y1 - 2018/11

N2 - Background: Cannabis use in young people is common and associated with psychiatric disorders. However, the prospective link between cannabis use and bipolar disorder symptoms has rarely been investigated. The study hypothesis was that adolescent cannabis use is associated with hypomania in early adulthood via several potential etiological pathways.Methods: Data were used from the Avon Longitudinal Study of Parents and Children, a UK birth cohort study. The prospective link between cannabis use at age 17 and hypomania at age 22-23 years was tested using regression analysis, adjusted for gender, early environmental risk factors, alcohol and drug use, and depression and psychotic symptoms at age 18 years. Path analysis examined direct and indirect effects of the link and whether gender, childhood family adversity, or childhood abuse are associated with hypomania via an increased risk of cannabis use.Results: Data were available on 3370 participants. Cannabis use at least 2-3 times weekly was associated with later hypomania (OR = 2.21, 95% CI = 1.49-3.28) after adjustment. There was a dose-response relationship (any use vs weekly). Cannabis use mediated the association of both childhood sexual abuse and hypomania, and male gender and hypomania. The cannabis use-hypomania link was not mediated by depression or psychotic symptoms.Conclusions: Adolescent cannabis use may be an independent risk factor for future hypomania, and the nature of the association suggests a potential causal link. Cannabis use mediates the link between childhood abuse and future hypomania. As such it might be a useful target for indicated prevention of hypomania.

AB - Background: Cannabis use in young people is common and associated with psychiatric disorders. However, the prospective link between cannabis use and bipolar disorder symptoms has rarely been investigated. The study hypothesis was that adolescent cannabis use is associated with hypomania in early adulthood via several potential etiological pathways.Methods: Data were used from the Avon Longitudinal Study of Parents and Children, a UK birth cohort study. The prospective link between cannabis use at age 17 and hypomania at age 22-23 years was tested using regression analysis, adjusted for gender, early environmental risk factors, alcohol and drug use, and depression and psychotic symptoms at age 18 years. Path analysis examined direct and indirect effects of the link and whether gender, childhood family adversity, or childhood abuse are associated with hypomania via an increased risk of cannabis use.Results: Data were available on 3370 participants. Cannabis use at least 2-3 times weekly was associated with later hypomania (OR = 2.21, 95% CI = 1.49-3.28) after adjustment. There was a dose-response relationship (any use vs weekly). Cannabis use mediated the association of both childhood sexual abuse and hypomania, and male gender and hypomania. The cannabis use-hypomania link was not mediated by depression or psychotic symptoms.Conclusions: Adolescent cannabis use may be an independent risk factor for future hypomania, and the nature of the association suggests a potential causal link. Cannabis use mediates the link between childhood abuse and future hypomania. As such it might be a useful target for indicated prevention of hypomania.

KW - cannabis

KW - mania

KW - psychopathology

KW - birth cohort

KW - child abuse

KW - ALSPAC

KW - adolescents

U2 - 10.1093/schbul/sbx158

DO - 10.1093/schbul/sbx158

M3 - Article

C2 - 29207008

VL - 44

SP - 1267

EP - 1274

JO - Schizophrenia bulletin

JF - Schizophrenia bulletin

SN - 0586-7614

IS - 6

ER -