Candidalysin is required for neutrophil recruitment and virulence during systemic candida albicans infection

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Candidalysin is required for neutrophil recruitment and virulence during systemic candida albicans infection. / Swidergall, Marc ; Khalaji, Mina ; Solis, Norma V ; Moyes, David ; Drummond, Rebecca; Hube, Bernhard; Lionakis, Michail S; Murdoch, Craig; Filler, Scott G; Naglik, Julian R.

In: The Journal of Infectious Diseases, Vol. 220, No. 9, 01.11.2019, p. 1477–1488.

Research output: Contribution to journalArticle

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Swidergall, M, Khalaji, M, Solis, NV, Moyes, D, Drummond, R, Hube, B, Lionakis, MS, Murdoch, C, Filler, SG & Naglik, JR 2019, 'Candidalysin is required for neutrophil recruitment and virulence during systemic candida albicans infection', The Journal of Infectious Diseases, vol. 220, no. 9, pp. 1477–1488. https://doi.org/10.1093/infdis/jiz322

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Author

Swidergall, Marc ; Khalaji, Mina ; Solis, Norma V ; Moyes, David ; Drummond, Rebecca ; Hube, Bernhard ; Lionakis, Michail S ; Murdoch, Craig ; Filler, Scott G ; Naglik, Julian R. / Candidalysin is required for neutrophil recruitment and virulence during systemic candida albicans infection. In: The Journal of Infectious Diseases. 2019 ; Vol. 220, No. 9. pp. 1477–1488.

Bibtex

@article{663cbd8fe4a04f96b98a6cbbcafea5d7,
title = "Candidalysin is required for neutrophil recruitment and virulence during systemic candida albicans infection",
abstract = "Background: Candidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis. Candidalysin is critical for mucosal C albicans infections and is known to activate epithelial cells to induce downstream innate immune responses that are associated with protection or immunopathology during oral or vaginal infections. Furthermore, candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. However, the role of candidalysin in driving systemic infections is unknown. Methods: In this study, using candidalysin-producing and candidalysin-deficient C albicans strains, we show that candidalysin activates mitogen-activated protein kinase (MAPK) signaling and chemokine secretion in endothelial cells in vitro. Results: Candidalysin induces immune activation and neutrophil recruitment in vivo, and it promotes mortality in zebrafish and murine models of systemic fungal infection. Conclusions: The data demonstrate a key role for candidalysin in neutrophil recruitment and fungal virulence during disseminated systemic C albicans infections.",
keywords = "Candida albicans, candidalysin, fungal, systemic, endothelial",
author = "Marc Swidergall and Mina Khalaji and Solis, {Norma V} and David Moyes and Rebecca Drummond and Bernhard Hube and Lionakis, {Michail S} and Craig Murdoch and Filler, {Scott G} and Naglik, {Julian R}",
year = "2019",
month = "11",
day = "1",
doi = "10.1093/infdis/jiz322",
language = "English",
volume = "220",
pages = "1477–1488",
journal = "The Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Candidalysin is required for neutrophil recruitment and virulence during systemic candida albicans infection

AU - Swidergall, Marc

AU - Khalaji, Mina

AU - Solis, Norma V

AU - Moyes, David

AU - Drummond, Rebecca

AU - Hube, Bernhard

AU - Lionakis, Michail S

AU - Murdoch, Craig

AU - Filler, Scott G

AU - Naglik, Julian R

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Background: Candidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis. Candidalysin is critical for mucosal C albicans infections and is known to activate epithelial cells to induce downstream innate immune responses that are associated with protection or immunopathology during oral or vaginal infections. Furthermore, candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. However, the role of candidalysin in driving systemic infections is unknown. Methods: In this study, using candidalysin-producing and candidalysin-deficient C albicans strains, we show that candidalysin activates mitogen-activated protein kinase (MAPK) signaling and chemokine secretion in endothelial cells in vitro. Results: Candidalysin induces immune activation and neutrophil recruitment in vivo, and it promotes mortality in zebrafish and murine models of systemic fungal infection. Conclusions: The data demonstrate a key role for candidalysin in neutrophil recruitment and fungal virulence during disseminated systemic C albicans infections.

AB - Background: Candidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis. Candidalysin is critical for mucosal C albicans infections and is known to activate epithelial cells to induce downstream innate immune responses that are associated with protection or immunopathology during oral or vaginal infections. Furthermore, candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. However, the role of candidalysin in driving systemic infections is unknown. Methods: In this study, using candidalysin-producing and candidalysin-deficient C albicans strains, we show that candidalysin activates mitogen-activated protein kinase (MAPK) signaling and chemokine secretion in endothelial cells in vitro. Results: Candidalysin induces immune activation and neutrophil recruitment in vivo, and it promotes mortality in zebrafish and murine models of systemic fungal infection. Conclusions: The data demonstrate a key role for candidalysin in neutrophil recruitment and fungal virulence during disseminated systemic C albicans infections.

KW - Candida albicans

KW - candidalysin

KW - fungal

KW - systemic

KW - endothelial

UR - http://www.scopus.com/inward/record.url?scp=85072716817&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiz322

DO - 10.1093/infdis/jiz322

M3 - Article

VL - 220

SP - 1477

EP - 1488

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

SN - 0022-1899

IS - 9

ER -