Calcium silicate/calcium aluminate composite biocement for bone restorative application: synthesis, characterisation and in vitro biocompatibility

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  • Central South University China


Pure β-dicalcium silicate and monocalcium aluminate powder were prepared by Pechini method. A series of calcium silicate/calcium aluminate cements (CSC/CAC) were prepared. The setting time, crystalline phases, microstructures, compressive strength, cells attachment and silicon release of the cements were investigated. The results indicate that the setting time of CSC/CAC was shorter than that of either CSC or CAC. The hydration products in CSC/CAC composite are gehlenite (Ca2Al2SiO7·8H2O), calcium aluminate hydrate (Ca3Al2O6× H2O), and katoite (Ca2Al2O6·6H2O). Platelike crystals were found in the microstructure. The liquid to powder ratio has a significant effect on the porosity and the strength of CSC/CAC. The MC3T3 cells attached well to the surfaces of CSC/CAC. However, the cells proliferation on the surface of 7S3A was better than that of 3S7A due to its higher silicon release. In general, CSC/CAC exhibits good biocompatibility and relative high strength, and may be suitable for some non-load bearing bone restorative applications.


Original languageEnglish
Pages (from-to)384-390
Number of pages7
JournalAdvances in Applied Ceramics
Issue number7
Publication statusPublished - 2 Oct 2016


  • Calcium aluminate cement, Calcium silicate cement, Composite, Hydration, Inorganic bone cement, Mechanical properties