Calbindin D-28k Positive Projection Neurones and Calretinin Positive Interneurones of the Rat Globus Pallidus

Alison Cooper; Ian Stanford

doi:10.1016/S0006-8993(01)03263-2

Calbindin D-28k Positive Projection Neurones and Calretinin Positive Interneurones of the Rat Globus Pallidus

Alison Cooper, Ian Stanford

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24 Citations (Scopus)

Abstract

Immunohistochemistry for three calcium-binding proteins calbindin D-28k, calretinin, and parvalbumin revealed neuronal heterogeneity within the GP. Each neurone appeared to express either a single type of calcium binding protein or none at all. The co-localisation of calcium binding proteins was not observed. Combined immunohistochemistry and retrograde tract tracing using colloidal gold particles injected into the projection fields, the substantia nigra or subthalamic nucleus, revealed that projection neurones could be labelled with either calbindin or parvalbumin. These cells were of medium size (22 x 12 microm), multipolar and moderate varicose dendritic trees. In contrast, calretinin-positive neurones were never retrogradely labelled, even in regions where neuronal colloidal gold deposits were numerous. This, combined with their rarity (

Original language	English
Pages (from-to)	243-251
Number of pages	9
Journal	Brain Research
Volume	929
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(01)03263-2
Publication status	Published - 8 Mar 2002

Keywords

colloidal gold
subthalamic nucleus
parvalbumin
substantia nigra
basal ganglia

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10.1016/S0006-8993(01)03263-2

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title = "Calbindin D-28k Positive Projection Neurones and Calretinin Positive Interneurones of the Rat Globus Pallidus",

abstract = "Immunohistochemistry for three calcium-binding proteins calbindin D-28k, calretinin, and parvalbumin revealed neuronal heterogeneity within the GP. Each neurone appeared to express either a single type of calcium binding protein or none at all. The co-localisation of calcium binding proteins was not observed. Combined immunohistochemistry and retrograde tract tracing using colloidal gold particles injected into the projection fields, the substantia nigra or subthalamic nucleus, revealed that projection neurones could be labelled with either calbindin or parvalbumin. These cells were of medium size (22 x 12 microm), multipolar and moderate varicose dendritic trees. In contrast, calretinin-positive neurones were never retrogradely labelled, even in regions where neuronal colloidal gold deposits were numerous. This, combined with their rarity (",

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T1 - Calbindin D-28k Positive Projection Neurones and Calretinin Positive Interneurones of the Rat Globus Pallidus

AU - Cooper, Alison

AU - Stanford, Ian

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N2 - Immunohistochemistry for three calcium-binding proteins calbindin D-28k, calretinin, and parvalbumin revealed neuronal heterogeneity within the GP. Each neurone appeared to express either a single type of calcium binding protein or none at all. The co-localisation of calcium binding proteins was not observed. Combined immunohistochemistry and retrograde tract tracing using colloidal gold particles injected into the projection fields, the substantia nigra or subthalamic nucleus, revealed that projection neurones could be labelled with either calbindin or parvalbumin. These cells were of medium size (22 x 12 microm), multipolar and moderate varicose dendritic trees. In contrast, calretinin-positive neurones were never retrogradely labelled, even in regions where neuronal colloidal gold deposits were numerous. This, combined with their rarity (

AB - Immunohistochemistry for three calcium-binding proteins calbindin D-28k, calretinin, and parvalbumin revealed neuronal heterogeneity within the GP. Each neurone appeared to express either a single type of calcium binding protein or none at all. The co-localisation of calcium binding proteins was not observed. Combined immunohistochemistry and retrograde tract tracing using colloidal gold particles injected into the projection fields, the substantia nigra or subthalamic nucleus, revealed that projection neurones could be labelled with either calbindin or parvalbumin. These cells were of medium size (22 x 12 microm), multipolar and moderate varicose dendritic trees. In contrast, calretinin-positive neurones were never retrogradely labelled, even in regions where neuronal colloidal gold deposits were numerous. This, combined with their rarity (

KW - colloidal gold

KW - subthalamic nucleus

KW - parvalbumin

KW - substantia nigra

KW - basal ganglia

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JO - Brain Research

JF - Brain Research

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Calbindin D-28k Positive Projection Neurones and Calretinin Positive Interneurones of the Rat Globus Pallidus

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Keywords

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