Calbindin D-28k Positive Projection Neurones and Calretinin Positive Interneurones of the Rat Globus Pallidus

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Colleges, School and Institutes


Immunohistochemistry for three calcium-binding proteins calbindin D-28k, calretinin, and parvalbumin revealed neuronal heterogeneity within the GP. Each neurone appeared to express either a single type of calcium binding protein or none at all. The co-localisation of calcium binding proteins was not observed. Combined immunohistochemistry and retrograde tract tracing using colloidal gold particles injected into the projection fields, the substantia nigra or subthalamic nucleus, revealed that projection neurones could be labelled with either calbindin or parvalbumin. These cells were of medium size (22 x 12 microm), multipolar and moderate varicose dendritic trees. In contrast, calretinin-positive neurones were never retrogradely labelled, even in regions where neuronal colloidal gold deposits were numerous. This, combined with their rarity (


Original languageEnglish
Pages (from-to)243-251
Number of pages9
JournalBrain Research
Issue number2
Publication statusPublished - 8 Mar 2002


  • colloidal gold, subthalamic nucleus, parvalbumin, substantia nigra, basal ganglia