Ca2+ signalling in the control of motility and guidance in mammalian sperm.

Research output: Contribution to journalArticle


  • LC Giojalas
  • ME Teves
  • GS de Oliveira
  • AA Garcia
  • CV Harper

Colleges, School and Institutes


Ca2+ signalling in the sperm plays a key role in the regulation of events preceding fertilisation. Control of motility, including hyperactivation and chemotaxis, is particularly dependent upon [Ca2+]i signalling in the principal piece of the flagellum and the midpiece. Here we briefly review the processes that contribute to regulation of [Ca2+]i in mammalian sperm and then examine two areas: (i) the regulation of hyperactivation by [Ca2+]i and the pivotal roles played by CatSpers (sperm-specific, Ca2+-permeable membrane channels) and intracellular Ca2+ stores in this process and (ii) the elevation of [Ca2+]i and consequent modulation of motility caused by progesterone including the ability of progesterone at micromolar concentrations to cause sperm hyperactivation and/or accumulation and the recent discovery that progesterone, at picomolar concentrations, acts as a chemoattractant for mammalian sperm..


Original languageEnglish
Pages (from-to)5623-37
Number of pages15
JournalFrontiers in Bioscience
Publication statusPublished - 1 Jan 2008


  • hyperactivation, calcium, motility, sperm, ryanodine receptor, CatSper, progesterone, chemotaxis, calcium store, review