Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores

Sanathana Konugolu Venkata  Sekar; Hamid Dehghani; Andrea Farino; Alberto Dalla  Mora; Claus Lindner; Marco  Pagliazzi; Mireia Mora; Gloria Aranda; Turgut Durduran; Paola Taroni; Antonio  Pifferi

doi:10.1038/s41598-018-27684-8

Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores

Sanathana Konugolu Venkata Sekar, Hamid Dehghani, Andrea Farino, Alberto Dalla Mora, Claus Lindner, Marco Pagliazzi, Mireia Mora, Gloria Aranda, Turgut Durduran, Paola Taroni, Antonio Pifferi

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Abstract

Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin – key tissue constituents specific to the thyroid organ – in the visible to near infrared range are not fully available. Here, we present the optical characterization of tyrosine (powder), thyroglobulin (granular form) and iodine (aqueous solution) using a time domain broadband diffuse optical spectrometer in the 550-1350 nm range. Various systematic errors caused by physics of photo migration and sample inherent properties were effectively suppressed by means of advanced time domain diffuse optical methods. A brief comparison with various other known tissue constituents is presented, which reveals key
spectral regions for the quantification of the thyroid absorbers in an in vivo scenario.

Original language	English
Journal	Scientific Reports
DOIs	https://doi.org/10.1038/s41598-018-27684-8
Publication status	Published - 3 Jul 2018

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title = "Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores",

abstract = "Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin – key tissue constituents specific to the thyroid organ – in the visible to near infrared range are not fully available. Here, we present the optical characterization of tyrosine (powder), thyroglobulin (granular form) and iodine (aqueous solution) using a time domain broadband diffuse optical spectrometer in the 550-1350 nm range. Various systematic errors caused by physics of photo migration and sample inherent properties were effectively suppressed by means of advanced time domain diffuse optical methods. A brief comparison with various other known tissue constituents is presented, which reveals keyspectral regions for the quantification of the thyroid absorbers in an in vivo scenario.",

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AU - Sekar, Sanathana Konugolu Venkata

AU - Dehghani, Hamid

AU - Farino, Andrea

AU - Mora, Alberto Dalla

AU - Lindner, Claus

AU - Pagliazzi, Marco

AU - Mora, Mireia

AU - Aranda, Gloria

AU - Durduran, Turgut

AU - Taroni, Paola

AU - Pifferi, Antonio

PY - 2018/7/3

Y1 - 2018/7/3

N2 - Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin – key tissue constituents specific to the thyroid organ – in the visible to near infrared range are not fully available. Here, we present the optical characterization of tyrosine (powder), thyroglobulin (granular form) and iodine (aqueous solution) using a time domain broadband diffuse optical spectrometer in the 550-1350 nm range. Various systematic errors caused by physics of photo migration and sample inherent properties were effectively suppressed by means of advanced time domain diffuse optical methods. A brief comparison with various other known tissue constituents is presented, which reveals keyspectral regions for the quantification of the thyroid absorbers in an in vivo scenario.

AB - Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin – key tissue constituents specific to the thyroid organ – in the visible to near infrared range are not fully available. Here, we present the optical characterization of tyrosine (powder), thyroglobulin (granular form) and iodine (aqueous solution) using a time domain broadband diffuse optical spectrometer in the 550-1350 nm range. Various systematic errors caused by physics of photo migration and sample inherent properties were effectively suppressed by means of advanced time domain diffuse optical methods. A brief comparison with various other known tissue constituents is presented, which reveals keyspectral regions for the quantification of the thyroid absorbers in an in vivo scenario.

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DO - 10.1038/s41598-018-27684-8

M3 - Article

JO - Scientific Reports

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Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores

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