Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores

Research output: Contribution to journalArticlepeer-review

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Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores. / Sekar, Sanathana Konugolu Venkata ; Dehghani, Hamid; Farino, Andrea; Mora, Alberto Dalla ; Lindner, Claus; Pagliazzi, Marco ; Mora, Mireia; Aranda, Gloria; Durduran, Turgut; Taroni, Paola; Pifferi, Antonio .

In: Scientific Reports, 03.07.2018.

Research output: Contribution to journalArticlepeer-review

Harvard

Sekar, SKV, Dehghani, H, Farino, A, Mora, AD, Lindner, C, Pagliazzi, M, Mora, M, Aranda, G, Durduran, T, Taroni, P & Pifferi, A 2018, 'Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores', Scientific Reports. https://doi.org/10.1038/s41598-018-27684-8

APA

Sekar, S. K. V., Dehghani, H., Farino, A., Mora, A. D., Lindner, C., Pagliazzi, M., Mora, M., Aranda, G., Durduran, T., Taroni, P., & Pifferi, A. (2018). Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores. Scientific Reports. https://doi.org/10.1038/s41598-018-27684-8

Vancouver

Author

Sekar, Sanathana Konugolu Venkata ; Dehghani, Hamid ; Farino, Andrea ; Mora, Alberto Dalla ; Lindner, Claus ; Pagliazzi, Marco ; Mora, Mireia ; Aranda, Gloria ; Durduran, Turgut ; Taroni, Paola ; Pifferi, Antonio . / Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores. In: Scientific Reports. 2018.

Bibtex

@article{ced07a2195bc4f42a8a235113bfc3758,
title = "Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores",
abstract = "Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin – key tissue constituents specific to the thyroid organ – in the visible to near infrared range are not fully available. Here, we present the optical characterization of tyrosine (powder), thyroglobulin (granular form) and iodine (aqueous solution) using a time domain broadband diffuse optical spectrometer in the 550-1350 nm range. Various systematic errors caused by physics of photo migration and sample inherent properties were effectively suppressed by means of advanced time domain diffuse optical methods. A brief comparison with various other known tissue constituents is presented, which reveals keyspectral regions for the quantification of the thyroid absorbers in an in vivo scenario.",
author = "Sekar, {Sanathana Konugolu Venkata} and Hamid Dehghani and Andrea Farino and Mora, {Alberto Dalla} and Claus Lindner and Marco Pagliazzi and Mireia Mora and Gloria Aranda and Turgut Durduran and Paola Taroni and Antonio Pifferi",
year = "2018",
month = jul,
day = "3",
doi = "10.1038/s41598-018-27684-8",
language = "English",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores

AU - Sekar, Sanathana Konugolu Venkata

AU - Dehghani, Hamid

AU - Farino, Andrea

AU - Mora, Alberto Dalla

AU - Lindner, Claus

AU - Pagliazzi, Marco

AU - Mora, Mireia

AU - Aranda, Gloria

AU - Durduran, Turgut

AU - Taroni, Paola

AU - Pifferi, Antonio

PY - 2018/7/3

Y1 - 2018/7/3

N2 - Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin – key tissue constituents specific to the thyroid organ – in the visible to near infrared range are not fully available. Here, we present the optical characterization of tyrosine (powder), thyroglobulin (granular form) and iodine (aqueous solution) using a time domain broadband diffuse optical spectrometer in the 550-1350 nm range. Various systematic errors caused by physics of photo migration and sample inherent properties were effectively suppressed by means of advanced time domain diffuse optical methods. A brief comparison with various other known tissue constituents is presented, which reveals keyspectral regions for the quantification of the thyroid absorbers in an in vivo scenario.

AB - Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin – key tissue constituents specific to the thyroid organ – in the visible to near infrared range are not fully available. Here, we present the optical characterization of tyrosine (powder), thyroglobulin (granular form) and iodine (aqueous solution) using a time domain broadband diffuse optical spectrometer in the 550-1350 nm range. Various systematic errors caused by physics of photo migration and sample inherent properties were effectively suppressed by means of advanced time domain diffuse optical methods. A brief comparison with various other known tissue constituents is presented, which reveals keyspectral regions for the quantification of the thyroid absorbers in an in vivo scenario.

U2 - 10.1038/s41598-018-27684-8

DO - 10.1038/s41598-018-27684-8

M3 - Article

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

ER -