Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores

Research output: Contribution to journalArticle

Authors

  • Sanathana Konugolu Venkata Sekar
  • Andrea Farino
  • Alberto Dalla Mora
  • Claus Lindner
  • Marco Pagliazzi
  • Mireia Mora
  • Gloria Aranda
  • Turgut Durduran
  • Paola Taroni
  • Antonio Pifferi

Colleges, School and Institutes

External organisations

  • Istituto di Fotonica e Nanotecnologie, Milano, Italy
  • Politecnico di Milano, Milano, Italy
  • ICFO-Institut de Ciències Fotòniques, Barcelona, Spain
  • Fundació Clínic per la Recerca Biomèdica, 08036 Barcelona, Spain
  • Hospital Clínic of Barcelona, Barcelona, Spain
  • Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

Abstract

Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin – key tissue constituents specific to the thyroid organ – in the visible to near infrared range are not fully available. Here, we present the optical characterization of tyrosine (powder), thyroglobulin (granular form) and iodine (aqueous solution) using a time domain broadband diffuse optical spectrometer in the 550-1350 nm range. Various systematic errors caused by physics of photo migration and sample inherent properties were effectively suppressed by means of advanced time domain diffuse optical methods. A brief comparison with various other known tissue constituents is presented, which reveals key
spectral regions for the quantification of the thyroid absorbers in an in vivo scenario.

Details

Original languageEnglish
JournalScientific Reports
Publication statusPublished - 3 Jul 2018