Brief Report: Immunization of HIV-Infected Adults in the UK With Haemophilus influenzae b/Meningococcal C Glycoconjugate and Pneumococcal Polysaccharide Vaccines

Calman A MacLennan, Alex Richter, James Hodson, Sian Faustini, Jane Birtwistle, Alison Whitelegg, Joyful Chigiga, Mebie Singo, Jodie Walker-Haywood, Betselot Mulugeta, Sindiso Masuka, Chris Mainey, Tim Plant, Mark T Drayson, Kaveh Manavi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

U.K. guidelines for vaccinating HIV-infected adults against bacteria are based on limited data. We compared antibody responses between 211 HIV-infected and 73 HIV-uninfected adults vaccinated with pneumococcal polysaccharide vaccine (PPV) and Haemophilus influenzae b/meningococcal C polysaccharide-tetanus toxoid glycoconjugate vaccine (Hib/MenC-TT). IgG responses to Hib/MenC-TT were not significantly different. PPV induced median IgGs >1.3 μg/mL for 10/12 serotypes among HIV-uninfected participants and 5/12 in HIV-infected participants. HIV-uninfected adults had higher post-vaccination IgGs than HIV-infected adults for 4/12 serotypes (P < 0.001). Responses did not associate with CD4 count or viral suppression. In a U.K. HIV-infected population, Hib/MenC-TT induced similar responses to HIV-uninfected adults, whereas PPV induced poor responses.

Original languageEnglish
Pages (from-to)287-293
Number of pages7
JournalJAIDS
Volume73
Issue number3
DOIs
Publication statusPublished - 1 Nov 2016

Fingerprint

Dive into the research topics of 'Brief Report: Immunization of HIV-Infected Adults in the UK With Haemophilus influenzae b/Meningococcal C Glycoconjugate and Pneumococcal Polysaccharide Vaccines'. Together they form a unique fingerprint.

Cite this