BRCA1-BARD1: the importance of being in shape

Research output: Contribution to journalArticle

Colleges, School and Institutes

Abstract

The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimportant to homologous recombination repair, indicating separate roles for BRCA1 in these pathways.

Details

Original languageEnglish
Article numbere1656500
JournalMolecular and Cellular Oncology
Volume6
Issue number6
Early online date11 Sep 2019
Publication statusPublished - 2 Nov 2019

Keywords

  • BRCA1, BARD1, PIN1, fork protection, isomerization, RAD51