BRCA1-BARD1: the importance of being in shape
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimportant to homologous recombination repair, indicating separate roles for BRCA1 in these pathways.
|Journal||Molecular and Cellular Oncology|
|Early online date||11 Sep 2019|
|Publication status||Published - 2 Nov 2019|
- BRCA1, BARD1, PIN1, fork protection, isomerization, RAD51