BRCA1-BARD1: the importance of being in shape
Research output: Contribution to journal › Article
Authors
Colleges, School and Institutes
Abstract
The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimportant to homologous recombination repair, indicating separate roles for BRCA1 in these pathways.
Details
| Original language | English |
|---|---|
| Article number | e1656500 |
| Journal | Molecular and Cellular Oncology |
| Volume | 6 |
| Issue number | 6 |
| Early online date | 11 Sep 2019 |
| Publication status | Published - 2 Nov 2019 |
Keywords
- BRCA1, BARD1, PIN1, fork protection, isomerization, RAD51