Brain MRI to personalise atrial fibrillation therapy: current evidence and perspectives

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Brain MRI to personalise atrial fibrillation therapy : current evidence and perspectives. / Haeusler, Karl Georg; Wilson, Duncan; Fiebach, Jochen B; Kirchhof, Paulus; Werring, David J.

In: Heart, Vol. 100, No. 18, 20.06.2014, p. 1408-1413.

Research output: Contribution to journalReview articlepeer-review

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Haeusler, Karl Georg ; Wilson, Duncan ; Fiebach, Jochen B ; Kirchhof, Paulus ; Werring, David J. / Brain MRI to personalise atrial fibrillation therapy : current evidence and perspectives. In: Heart. 2014 ; Vol. 100, No. 18. pp. 1408-1413.

Bibtex

@article{0ab782fe0c4b4715adae9214de16ae79,
title = "Brain MRI to personalise atrial fibrillation therapy: current evidence and perspectives",
abstract = "Advances in the access to and in the performance of brain MRI have led to an increased detection of asymptomatic abnormalities in the brain of patients with cardiovascular diseases. These may have prognostic impact and could influence management in the future. In this review, we summarise the main findings of brain MRI in patients with atrial fibrillation (AF) and explore the available evidence to better quantify the risk for intracerebral haemorrhage and (recurrent) ischaemic stroke based on brain MRI findings. Treatment decisions in the majority of patients with AF should still be based on data from established validated risk scores and large randomised trials. Whether brain MRI has the potential to improve the personalised management of patients with AF by guiding the risk and benefit assessment of stroke prevention by oral anticoagulants remains to be established in large prospective studies using standardised brain MRI. However, even today, brain MRI may help to identify subsets of patients with AF at increased risk for (recurrent) intracerebral bleeding. Although present knowledge and MRI-associated costs do not support routine use of brain MRI in asymptomatic patients with AF, as more data emerge MRI may become an increasingly useful way to stratify patients with AF and individualise their treatment.",
keywords = "Administration, Oral, Anticoagulants, Atrial Fibrillation, Brain, Humans, Intracranial Embolism, Intracranial Hemorrhages, Magnetic Resonance Imaging, Precision Medicine, Predictive Value of Tests, Risk Assessment, Risk Factors, Stroke, Treatment Outcome",
author = "Haeusler, {Karl Georg} and Duncan Wilson and Fiebach, {Jochen B} and Paulus Kirchhof and Werring, {David J}",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",
year = "2014",
month = jun,
day = "20",
doi = "10.1136/heartjnl-2013-305151",
language = "English",
volume = "100",
pages = "1408--1413",
journal = "Heart",
issn = "1355-6037",
publisher = "BMJ Publishing Group",
number = "18",

}

RIS

TY - JOUR

T1 - Brain MRI to personalise atrial fibrillation therapy

T2 - current evidence and perspectives

AU - Haeusler, Karl Georg

AU - Wilson, Duncan

AU - Fiebach, Jochen B

AU - Kirchhof, Paulus

AU - Werring, David J

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2014/6/20

Y1 - 2014/6/20

N2 - Advances in the access to and in the performance of brain MRI have led to an increased detection of asymptomatic abnormalities in the brain of patients with cardiovascular diseases. These may have prognostic impact and could influence management in the future. In this review, we summarise the main findings of brain MRI in patients with atrial fibrillation (AF) and explore the available evidence to better quantify the risk for intracerebral haemorrhage and (recurrent) ischaemic stroke based on brain MRI findings. Treatment decisions in the majority of patients with AF should still be based on data from established validated risk scores and large randomised trials. Whether brain MRI has the potential to improve the personalised management of patients with AF by guiding the risk and benefit assessment of stroke prevention by oral anticoagulants remains to be established in large prospective studies using standardised brain MRI. However, even today, brain MRI may help to identify subsets of patients with AF at increased risk for (recurrent) intracerebral bleeding. Although present knowledge and MRI-associated costs do not support routine use of brain MRI in asymptomatic patients with AF, as more data emerge MRI may become an increasingly useful way to stratify patients with AF and individualise their treatment.

AB - Advances in the access to and in the performance of brain MRI have led to an increased detection of asymptomatic abnormalities in the brain of patients with cardiovascular diseases. These may have prognostic impact and could influence management in the future. In this review, we summarise the main findings of brain MRI in patients with atrial fibrillation (AF) and explore the available evidence to better quantify the risk for intracerebral haemorrhage and (recurrent) ischaemic stroke based on brain MRI findings. Treatment decisions in the majority of patients with AF should still be based on data from established validated risk scores and large randomised trials. Whether brain MRI has the potential to improve the personalised management of patients with AF by guiding the risk and benefit assessment of stroke prevention by oral anticoagulants remains to be established in large prospective studies using standardised brain MRI. However, even today, brain MRI may help to identify subsets of patients with AF at increased risk for (recurrent) intracerebral bleeding. Although present knowledge and MRI-associated costs do not support routine use of brain MRI in asymptomatic patients with AF, as more data emerge MRI may become an increasingly useful way to stratify patients with AF and individualise their treatment.

KW - Administration, Oral

KW - Anticoagulants

KW - Atrial Fibrillation

KW - Brain

KW - Humans

KW - Intracranial Embolism

KW - Intracranial Hemorrhages

KW - Magnetic Resonance Imaging

KW - Precision Medicine

KW - Predictive Value of Tests

KW - Risk Assessment

KW - Risk Factors

KW - Stroke

KW - Treatment Outcome

U2 - 10.1136/heartjnl-2013-305151

DO - 10.1136/heartjnl-2013-305151

M3 - Review article

C2 - 24951485

VL - 100

SP - 1408

EP - 1413

JO - Heart

JF - Heart

SN - 1355-6037

IS - 18

ER -