Brain activation during memory encoding in Type 2 diabetes mellitus – a discordant twin pair study

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Brain activation during memory encoding in Type 2 diabetes mellitus – a discordant twin pair study. / Wood, Amanda; Chen, Jian; Moran, Christopher; Phan, Thanh G; Beare, Richard; Cooper, Kimberlea; Litras, Stacey; Srikanth, Velandai.

In: Journal of Diabetes Research, Vol. 2016, 3978428, 2016.

Research output: Contribution to journalArticle

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APA

Wood, A., Chen, J., Moran, C., Phan, T. G., Beare, R., Cooper, K., Litras, S., & Srikanth, V. (2016). Brain activation during memory encoding in Type 2 diabetes mellitus – a discordant twin pair study. Journal of Diabetes Research, 2016, [3978428]. https://doi.org/10.1155/2016/3978428

Vancouver

Author

Wood, Amanda ; Chen, Jian ; Moran, Christopher ; Phan, Thanh G ; Beare, Richard ; Cooper, Kimberlea ; Litras, Stacey ; Srikanth, Velandai. / Brain activation during memory encoding in Type 2 diabetes mellitus – a discordant twin pair study. In: Journal of Diabetes Research. 2016 ; Vol. 2016.

Bibtex

@article{5317c3a41a84454c9cc56c87e620759a,
title = "Brain activation during memory encoding in Type 2 diabetes mellitus – a discordant twin pair study",
abstract = "Type 2 diabetes mellitus increases the risk of dementia and neuronal dysfunction may occur years before perceptible cognitive decline. We aimed to study the impact of type 2 diabetes on brain activation during memory encoding in middle-aged people, controlling for age, sex, genes, and early-shared environment. Twenty-two twin pairs discordant for type 2 diabetes mellitus (mean age 60.9 years) without neurological disease were recruited from the Australian Twin Registry (ATR) and underwent functional magnetic resonance imaging (fMRI) during a memory encoding task, cognitive tests, and structural MRI. Type 2 diabetes was associated with significantly reduced activation in left hemisphere temporoparietal regions including angular gyrus, supramarginal gyrus, and middle temporal gyrus and significantly increased activation in bilateral posteriorly distributed regions. These findings were present in the absence of within-pair differences in standard cognitive test scores, brain volumes, or vascular lesion load. Differences in activation were more pronounced among monozygotic (MZ) pairs, with MZ individuals with diabetes also displaying greater frontal activation. These results provide evidence for preclinical memory-related neuronal dysfunction in type 2 diabetes. They support the search for modifiable later-life environmental factors or epigenetic mechanisms linking type 2 diabetes and cognitive decline.",
author = "Amanda Wood and Jian Chen and Christopher Moran and Phan, {Thanh G} and Richard Beare and Kimberlea Cooper and Stacey Litras and Velandai Srikanth",
year = "2016",
doi = "10.1155/2016/3978428",
language = "English",
volume = "2016",
journal = "Journal of Diabetes Research",
issn = "2314-6745",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Brain activation during memory encoding in Type 2 diabetes mellitus – a discordant twin pair study

AU - Wood, Amanda

AU - Chen, Jian

AU - Moran, Christopher

AU - Phan, Thanh G

AU - Beare, Richard

AU - Cooper, Kimberlea

AU - Litras, Stacey

AU - Srikanth, Velandai

PY - 2016

Y1 - 2016

N2 - Type 2 diabetes mellitus increases the risk of dementia and neuronal dysfunction may occur years before perceptible cognitive decline. We aimed to study the impact of type 2 diabetes on brain activation during memory encoding in middle-aged people, controlling for age, sex, genes, and early-shared environment. Twenty-two twin pairs discordant for type 2 diabetes mellitus (mean age 60.9 years) without neurological disease were recruited from the Australian Twin Registry (ATR) and underwent functional magnetic resonance imaging (fMRI) during a memory encoding task, cognitive tests, and structural MRI. Type 2 diabetes was associated with significantly reduced activation in left hemisphere temporoparietal regions including angular gyrus, supramarginal gyrus, and middle temporal gyrus and significantly increased activation in bilateral posteriorly distributed regions. These findings were present in the absence of within-pair differences in standard cognitive test scores, brain volumes, or vascular lesion load. Differences in activation were more pronounced among monozygotic (MZ) pairs, with MZ individuals with diabetes also displaying greater frontal activation. These results provide evidence for preclinical memory-related neuronal dysfunction in type 2 diabetes. They support the search for modifiable later-life environmental factors or epigenetic mechanisms linking type 2 diabetes and cognitive decline.

AB - Type 2 diabetes mellitus increases the risk of dementia and neuronal dysfunction may occur years before perceptible cognitive decline. We aimed to study the impact of type 2 diabetes on brain activation during memory encoding in middle-aged people, controlling for age, sex, genes, and early-shared environment. Twenty-two twin pairs discordant for type 2 diabetes mellitus (mean age 60.9 years) without neurological disease were recruited from the Australian Twin Registry (ATR) and underwent functional magnetic resonance imaging (fMRI) during a memory encoding task, cognitive tests, and structural MRI. Type 2 diabetes was associated with significantly reduced activation in left hemisphere temporoparietal regions including angular gyrus, supramarginal gyrus, and middle temporal gyrus and significantly increased activation in bilateral posteriorly distributed regions. These findings were present in the absence of within-pair differences in standard cognitive test scores, brain volumes, or vascular lesion load. Differences in activation were more pronounced among monozygotic (MZ) pairs, with MZ individuals with diabetes also displaying greater frontal activation. These results provide evidence for preclinical memory-related neuronal dysfunction in type 2 diabetes. They support the search for modifiable later-life environmental factors or epigenetic mechanisms linking type 2 diabetes and cognitive decline.

U2 - 10.1155/2016/3978428

DO - 10.1155/2016/3978428

M3 - Article

VL - 2016

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

SN - 2314-6745

M1 - 3978428

ER -