Both substrate availability and utilisation contribute to the defence of core temperature in response to acute cold

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@article{55eeffc565664f8dbdee3a3ed7b6d2cf,
title = "Both substrate availability and utilisation contribute to the defence of core temperature in response to acute cold",
abstract = "Acute cooling significantly increases energy demand in non-hibernators for the defence of core temperature but the contribution of the liver to thermogenesis is poorly understood. A two-tracer method to estimate lipid metabolism in cold-naive control (CON) and cold-acclimated (CA) rats was employed to quantify hepatic rates of fat metabolism. Both fenofibrate, to increase liver mass and fat oxidation and dichloroacetate (DCA) to inhibit fat oxidation were used to alter lipid metabolism in CON animals. Following acute cooling, CA led to a doubling of the time to reach a core temperature 25 degrees C (P",
keywords = "Utilisation, Fatty acid, Metabolism, Cold acclimation",
author = "David Hauton and Andrew Coney and Stuart Egginton",
year = "2009",
month = dec,
day = "1",
doi = "10.1016/j.cbpa.2009.08.008",
language = "English",
volume = "154",
pages = "514--522",
journal = "Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology",
issn = "1095-6433",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Both substrate availability and utilisation contribute to the defence of core temperature in response to acute cold

AU - Hauton, David

AU - Coney, Andrew

AU - Egginton, Stuart

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Acute cooling significantly increases energy demand in non-hibernators for the defence of core temperature but the contribution of the liver to thermogenesis is poorly understood. A two-tracer method to estimate lipid metabolism in cold-naive control (CON) and cold-acclimated (CA) rats was employed to quantify hepatic rates of fat metabolism. Both fenofibrate, to increase liver mass and fat oxidation and dichloroacetate (DCA) to inhibit fat oxidation were used to alter lipid metabolism in CON animals. Following acute cooling, CA led to a doubling of the time to reach a core temperature 25 degrees C (P

AB - Acute cooling significantly increases energy demand in non-hibernators for the defence of core temperature but the contribution of the liver to thermogenesis is poorly understood. A two-tracer method to estimate lipid metabolism in cold-naive control (CON) and cold-acclimated (CA) rats was employed to quantify hepatic rates of fat metabolism. Both fenofibrate, to increase liver mass and fat oxidation and dichloroacetate (DCA) to inhibit fat oxidation were used to alter lipid metabolism in CON animals. Following acute cooling, CA led to a doubling of the time to reach a core temperature 25 degrees C (P

KW - Utilisation

KW - Fatty acid

KW - Metabolism

KW - Cold acclimation

U2 - 10.1016/j.cbpa.2009.08.008

DO - 10.1016/j.cbpa.2009.08.008

M3 - Article

C2 - 19712745

VL - 154

SP - 514

EP - 522

JO - Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology

JF - Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology

SN - 1095-6433

IS - 4

ER -