Both substrate availability and utilisation contribute to the defence of core temperature in response to acute cold

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Acute cooling significantly increases energy demand in non-hibernators for the defence of core temperature but the contribution of the liver to thermogenesis is poorly understood. A two-tracer method to estimate lipid metabolism in cold-naive control (CON) and cold-acclimated (CA) rats was employed to quantify hepatic rates of fat metabolism. Both fenofibrate, to increase liver mass and fat oxidation and dichloroacetate (DCA) to inhibit fat oxidation were used to alter lipid metabolism in CON animals. Following acute cooling, CA led to a doubling of the time to reach a core temperature 25 degrees C (P


Original languageEnglish
Pages (from-to)514-522
Number of pages9
JournalComparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology
Issue number4
Publication statusPublished - 1 Dec 2009


  • Utilisation, Fatty acid, Metabolism, Cold acclimation