BMP signalling differentially regulates distinct haematopoietic stem cell types

Research output: Contribution to journalArticlepeer-review

Standard

BMP signalling differentially regulates distinct haematopoietic stem cell types. / Crisan, Mihaela; Kartalaei, Parham Solaimani; Vink, Chris; Yamada-Inagawa, Tomoko; Bollerot, Karine; Van Ijcken, Wilfred; Van Der Linden, Reinier; De Sousa Lopes, Susana M.Chuva; Monteiro, Rui; Mummery, Christine; Dzierzak, Elaine.

In: Nature Communications, Vol. 6, 8040, 18.08.2015.

Research output: Contribution to journalArticlepeer-review

Harvard

Crisan, M, Kartalaei, PS, Vink, C, Yamada-Inagawa, T, Bollerot, K, Van Ijcken, W, Van Der Linden, R, De Sousa Lopes, SMC, Monteiro, R, Mummery, C & Dzierzak, E 2015, 'BMP signalling differentially regulates distinct haematopoietic stem cell types', Nature Communications, vol. 6, 8040. https://doi.org/10.1038/ncomms9040

APA

Crisan, M., Kartalaei, P. S., Vink, C., Yamada-Inagawa, T., Bollerot, K., Van Ijcken, W., Van Der Linden, R., De Sousa Lopes, S. M. C., Monteiro, R., Mummery, C., & Dzierzak, E. (2015). BMP signalling differentially regulates distinct haematopoietic stem cell types. Nature Communications, 6, [8040]. https://doi.org/10.1038/ncomms9040

Vancouver

Crisan M, Kartalaei PS, Vink C, Yamada-Inagawa T, Bollerot K, Van Ijcken W et al. BMP signalling differentially regulates distinct haematopoietic stem cell types. Nature Communications. 2015 Aug 18;6. 8040. https://doi.org/10.1038/ncomms9040

Author

Crisan, Mihaela ; Kartalaei, Parham Solaimani ; Vink, Chris ; Yamada-Inagawa, Tomoko ; Bollerot, Karine ; Van Ijcken, Wilfred ; Van Der Linden, Reinier ; De Sousa Lopes, Susana M.Chuva ; Monteiro, Rui ; Mummery, Christine ; Dzierzak, Elaine. / BMP signalling differentially regulates distinct haematopoietic stem cell types. In: Nature Communications. 2015 ; Vol. 6.

Bibtex

@article{1191d7f4b874498183f336cadb1794b0,
title = "BMP signalling differentially regulates distinct haematopoietic stem cell types",
abstract = "Adult haematopoiesis is the outcome of distinct haematopoietic stem cell (HSC) subtypes with self-renewable repopulating ability, but with different haematopoietic cell lineage outputs. The molecular basis for this heterogeneity is largely unknown. BMP signalling regulates HSCs as they are first generated in the aorta-gonad-mesonephros region, but at later developmental stages, its role in HSCs is controversial. Here we show that HSCs in murine fetal liver and the bone marrow are of two types that can be prospectively isolated - BMP activated and non-BMP activated. Clonal transplantation demonstrates that they have distinct haematopoietic lineage outputs. Moreover, the two HSC types differ in intrinsic genetic programs, thus supporting a role for the BMP signalling axis in the regulation of HSC heterogeneity and lineage output. Our findings provide insight into the molecular control mechanisms that define HSC types and have important implications for reprogramming cells to HSC fate and treatments targeting distinct HSC types.",
author = "Mihaela Crisan and Kartalaei, {Parham Solaimani} and Chris Vink and Tomoko Yamada-Inagawa and Karine Bollerot and {Van Ijcken}, Wilfred and {Van Der Linden}, Reinier and {De Sousa Lopes}, {Susana M.Chuva} and Rui Monteiro and Christine Mummery and Elaine Dzierzak",
year = "2015",
month = aug,
day = "18",
doi = "10.1038/ncomms9040",
language = "English",
volume = "6",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - BMP signalling differentially regulates distinct haematopoietic stem cell types

AU - Crisan, Mihaela

AU - Kartalaei, Parham Solaimani

AU - Vink, Chris

AU - Yamada-Inagawa, Tomoko

AU - Bollerot, Karine

AU - Van Ijcken, Wilfred

AU - Van Der Linden, Reinier

AU - De Sousa Lopes, Susana M.Chuva

AU - Monteiro, Rui

AU - Mummery, Christine

AU - Dzierzak, Elaine

PY - 2015/8/18

Y1 - 2015/8/18

N2 - Adult haematopoiesis is the outcome of distinct haematopoietic stem cell (HSC) subtypes with self-renewable repopulating ability, but with different haematopoietic cell lineage outputs. The molecular basis for this heterogeneity is largely unknown. BMP signalling regulates HSCs as they are first generated in the aorta-gonad-mesonephros region, but at later developmental stages, its role in HSCs is controversial. Here we show that HSCs in murine fetal liver and the bone marrow are of two types that can be prospectively isolated - BMP activated and non-BMP activated. Clonal transplantation demonstrates that they have distinct haematopoietic lineage outputs. Moreover, the two HSC types differ in intrinsic genetic programs, thus supporting a role for the BMP signalling axis in the regulation of HSC heterogeneity and lineage output. Our findings provide insight into the molecular control mechanisms that define HSC types and have important implications for reprogramming cells to HSC fate and treatments targeting distinct HSC types.

AB - Adult haematopoiesis is the outcome of distinct haematopoietic stem cell (HSC) subtypes with self-renewable repopulating ability, but with different haematopoietic cell lineage outputs. The molecular basis for this heterogeneity is largely unknown. BMP signalling regulates HSCs as they are first generated in the aorta-gonad-mesonephros region, but at later developmental stages, its role in HSCs is controversial. Here we show that HSCs in murine fetal liver and the bone marrow are of two types that can be prospectively isolated - BMP activated and non-BMP activated. Clonal transplantation demonstrates that they have distinct haematopoietic lineage outputs. Moreover, the two HSC types differ in intrinsic genetic programs, thus supporting a role for the BMP signalling axis in the regulation of HSC heterogeneity and lineage output. Our findings provide insight into the molecular control mechanisms that define HSC types and have important implications for reprogramming cells to HSC fate and treatments targeting distinct HSC types.

UR - http://www.scopus.com/inward/record.url?scp=84939620073&partnerID=8YFLogxK

U2 - 10.1038/ncomms9040

DO - 10.1038/ncomms9040

M3 - Article

C2 - 26282601

AN - SCOPUS:84939620073

VL - 6

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 8040

ER -