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Abstract
The present invention concerns the use of protein biomarkers for use in facilitating in the prognosis and/or treatment regime of bladder cancer. In particular, the invention relates to the use of shed protein fragments, such as fragments of Epithelial cell adhesion molecule (EpCAM) and/or epidermal growth factor receptor (EGFR) detected in a sample of urine, as biomarkers for use in facilitating the prognosis and/or treatment regime of urothelial bladder cancer.
| Original language | English |
|---|---|
| Patent number | WO/2016/083832 |
| IPC | G01N 33/574 (2006.01), G01N 33/68 (2006.01) |
| Priority date | 28/11/14 |
| Publication status | Published - 2 Jun 2016 |
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Exploring the roles of urinary HAI-1, EpCAM & EGFR in bladder cancer prognosis & risk stratification
Snell, K., Ward, D., Gordon, N., Goldsmith, J., Sutton, A., Patel, P., James, N., Zeegers, M., Cheng, K. & Bryan, R., 18 May 2018, In: OncoTarget. 9, 38, p. 25244-25253 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)120 Downloads (Pure) -
Bladder cancer: Urinary EGFR and EpCAM predict cancer-specific survival
Sidaway, P., Bryan, R. & Ward, D., Apr 2015, In: Nature reviews. Urology. 12, 4, p. 184 1 p.Research output: Contribution to journal › Letter › peer-review
1 Citation (Scopus) -
Protein shedding in urothelial bladder cancer: prognostic implications of soluble urinary EGFR and EpCAM
Bryan, R. T., Regan, H. L., Pirrie, S. J., Devall, A. J., Cheng, K. K., Zeegers, M. P., James, N. D., Knowles, M. A. & Ward, D. G., 17 Mar 2015, In: British Journal of Cancer. 112, 6, p. 1052-8 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)180 Downloads (Pure) -
Urinary EpCAM in urothelial bladder cancer patients: characterisation and evaluation of biomarker potential
Bryan, R. T., Shimwell, N. J., Wei, W., Devall, A. J., Pirrie, S. J., James, N. D., Zeegers, M. P., Cheng, K. K., Martin, A. & Ward, D. G., 4 Feb 2014, In: British Journal of Cancer. 110, 3, p. 679-85 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (Scopus)156 Downloads (Pure) -
Combined proteome and transcriptome analyses for the discovery of urinary biomarkers for urothelial carcinoma
Shimwell, N., Bryan, R., Wei, W., James, N., Cheng, K., Zeegers, M., Johnson, P., Martin, A. & Ward, D., 14 May 2013, In: British Journal of Cancer. 108, 9, p. 1854-1861 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (Scopus)27 Downloads (Pure) -
Assessment of high-throughput high-resolution MALDI-TOF-MS of urinary peptides for the detection of muscle-invasive bladder cancer.
Bryan, R., Wei, W., Shimwell, N., Collins, S., Hussain, S., Billingham, L., Murray, P., Deshmukh, N., James, N., Wallace, DM., Johnson, P., Zeegers, M., Cheng, K., Martin, A. & Ward, D., 1 Oct 2011, In: Proteomics. Clinical applications. 5, 9-10, p. 493-503 11 p.Research output: Contribution to journal › Article
26 Citations (Scopus)
Projects
- 2 Finished