Birth weight and creatinine clearance in young adult twins: influence of genetic, prenatal, and maternal factors

Research output: Contribution to journalArticle


  • M Gielen
  • SJ Pinto-Sietsma
  • RJ Loos
  • R Fagard
  • PW de Leeuw
  • G Beunen
  • C Derom
  • R Vlietinck


Previous studies have shown that low birth weight (LBW) is a risk factor for renal impairment in adult life. The effects of LBW and renal function were studied by using twins, which allows distinguishing among fetoplacental, maternal, and genetic influences. Perinatal data were obtained at birth, and absolute creatinine clearance (not corrected for body surface area) was measured at a mean age of 25.6 yr in 653 individuals. Twins were considered both as individuals and as members of twin pairs. Statistical analyses were performed with and without adjusting for gestational age, zygosity, gender, age, body mass index, glucose level, BP, and smoking status. Creatinine clearance was 4 ml/min lower in twins with LBW (


Original languageEnglish
Pages (from-to)2471-2476
Number of pages6
JournalJournal of the American Society of Nephrology
Publication statusPublished - 29 Jun 2005