TY - JOUR
T1 - Bipolar disorder and variation at a common polymorphism (A1832G) within exon 8 of the wolfram gene
AU - Middle, Fiona
AU - Jones, Ian
AU - McCandless, Fiona
AU - Barrett, Tim
AU - Khanim, Farhat
AU - Owen, Michael J.
AU - Lendon, Corinne
AU - Craddock, Nick
PY - 2000/4/3
Y1 - 2000/4/3
N2 - A number of linkage studies provide evidence consistent with the existence of a bipolar susceptibility gene on chromosome 4p16. The gene for Wolfram syndrome, a rare recessive neurodegenerative disorder, lies in this region and has recently been cloned. Psychiatric disturbances including psychosis, mood disorder, and suicide have been reported at increased frequency in Wolfram patients and in heterozygous carriers of a Wolfram mutation. In the current investigation we have undertaken a case-control association study using a single nucleotide polymorphism (causing an amino acid change) in exon 8 of the Wolfram gene in a UK Caucasian sample of 312 Diagnostic and Statistical Manual of Mental Disorders (fourth edition; DSM IV) bipolar I probands and 301 comparison individuals. We found no evidence that variation at this polymorphism influences susceptibility to bipolar disorder. It remains possible that variation at other sites within or near the Wolfram gene plays important roles in determining susceptibility to affective illness. (C) 2000 Wiley-Liss, Inc.
AB - A number of linkage studies provide evidence consistent with the existence of a bipolar susceptibility gene on chromosome 4p16. The gene for Wolfram syndrome, a rare recessive neurodegenerative disorder, lies in this region and has recently been cloned. Psychiatric disturbances including psychosis, mood disorder, and suicide have been reported at increased frequency in Wolfram patients and in heterozygous carriers of a Wolfram mutation. In the current investigation we have undertaken a case-control association study using a single nucleotide polymorphism (causing an amino acid change) in exon 8 of the Wolfram gene in a UK Caucasian sample of 312 Diagnostic and Statistical Manual of Mental Disorders (fourth edition; DSM IV) bipolar I probands and 301 comparison individuals. We found no evidence that variation at this polymorphism influences susceptibility to bipolar disorder. It remains possible that variation at other sites within or near the Wolfram gene plays important roles in determining susceptibility to affective illness. (C) 2000 Wiley-Liss, Inc.
KW - Bipolar disorder
KW - Susceptibility gene
KW - Wolfram syndrome gene
UR - http://www.scopus.com/inward/record.url?scp=0034599508&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-8628(20000403)96:2<154::AID-AJMG5>3.0.CO;2-F
DO - 10.1002/(SICI)1096-8628(20000403)96:2<154::AID-AJMG5>3.0.CO;2-F
M3 - Article
C2 - 10893487
AN - SCOPUS:0034599508
SN - 1552-4841
VL - 96
SP - 154
EP - 157
JO - American Journal of Medical Genetics - Neuropsychiatric Genetics
JF - American Journal of Medical Genetics - Neuropsychiatric Genetics
IS - 2
ER -