Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging

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Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging. / Guggenheim, J.A.; Basevi, H.R.A.; Dehghani, H.; Styles, I.B.; Frampton, J.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8799 2013.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Guggenheim, J.A. ; Basevi, H.R.A. ; Dehghani, H. ; Styles, I.B. ; Frampton, J. / Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8799 2013.

Bibtex

@inbook{904e8a104788431c8b555c9bbf608b76,
title = "Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging",
abstract = "A study is presented that demonstrates that bioluminescence tomography can reconstruct accurate 3D images of internal light sources placed at a range of depths within a physical phantom and that it provides more reliable quantitative data than standard bioluminescence imaging. Specifically, it is shown that when imaging sources at depths ranging from 5 to 15mm, estimates of total source strength are stable to within ±11{\%} using tomography whilst values deduced by traditional methods vary 10-fold. Additionally, the tomographic approach correctly localises sources to within 1.5mm error in all cases considered.",
author = "J.A. Guggenheim and H.R.A. Basevi and H. Dehghani and I.B. Styles and J. Frampton",
year = "2013",
month = "6",
day = "25",
doi = "10.1117/12.2033317",
language = "English",
isbn = "9780819496485",
volume = "8799",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

RIS

TY - CHAP

T1 - Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging

AU - Guggenheim, J.A.

AU - Basevi, H.R.A.

AU - Dehghani, H.

AU - Styles, I.B.

AU - Frampton, J.

PY - 2013/6/25

Y1 - 2013/6/25

N2 - A study is presented that demonstrates that bioluminescence tomography can reconstruct accurate 3D images of internal light sources placed at a range of depths within a physical phantom and that it provides more reliable quantitative data than standard bioluminescence imaging. Specifically, it is shown that when imaging sources at depths ranging from 5 to 15mm, estimates of total source strength are stable to within ±11% using tomography whilst values deduced by traditional methods vary 10-fold. Additionally, the tomographic approach correctly localises sources to within 1.5mm error in all cases considered.

AB - A study is presented that demonstrates that bioluminescence tomography can reconstruct accurate 3D images of internal light sources placed at a range of depths within a physical phantom and that it provides more reliable quantitative data than standard bioluminescence imaging. Specifically, it is shown that when imaging sources at depths ranging from 5 to 15mm, estimates of total source strength are stable to within ±11% using tomography whilst values deduced by traditional methods vary 10-fold. Additionally, the tomographic approach correctly localises sources to within 1.5mm error in all cases considered.

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84881148782&partnerID=8YFLogxK

U2 - 10.1117/12.2033317

DO - 10.1117/12.2033317

M3 - Chapter

AN - SCOPUS:84881148782

SN - 9780819496485

VL - 8799

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -