Biological factors involved in alveolar bone regeneration: consensus report of Working Group 1 of the 15th European Workshop on Periodontology on Bone Regeneration

Research output: Contribution to journalArticlepeer-review


  • William V. Giannobile
  • Tord Berglundh
  • Bilal Al-nawas
  • Mauricio Araujo
  • P. Mark Bartold
  • Philippe Bouchard
  • Reinhard Gruber
  • Pernilla Lundberg
  • Anton Sculean
  • Niklaus P. Lang
  • Petter Lyngstadaas
  • Pablo Galindo-moreno
  • Zvi Schwartz
  • Lior Shapira
  • Andreas Stavropoulos
  • Janne Reseland

Colleges, School and Institutes

External organisations

  • University of Michigan
  • Department of Periodontology; Institute of Odontology; Sahlgrenska Academy; University of Gothenburg; Gothenburg Sweden
  • Department of Oral, Maxillofacial and Plastic Surgery; J. Gutenberg University of Mainz; Mainz Germany
  • State University of Maringa; Parana Brazil
  • University of Adelaide
  • Department of Periodontology; Paris 7 University; Paris France
  • University of Birmingham
  • Department of Oral Biology; Medical University of Vienna; Vienna Austria
  • Department of Odontology; Division of Molecular Periodontology; Umeå University; Umeå Sweden
  • Department of Periodontology; School of Dental Medicine; University of Bern; Bern Switzerland
  • University Hospital Zürich
  • University of Oslo
  • University of Granada
  • Department of Psychology, Tel Aviv University, Tel Aviv, Israel
  • Department of Periodontology, Hebrew University - Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
  • Department of Periodontology; Malmö University; Malmö Sweden


Background and Aims: To describe the biology of alveolar bone regeneration.

Material and Methods: Four comprehensive reviews were performed on (a) mesenchymal cells and differentiation factors leading to bone formation; (b) the critical interplay between bone resorbing and formative cells; (c) the role of osteoimmunology in the formation and maintenance of alveolar bone; and (d) the self‐regenerative capacity following bone injury or tooth extraction were prepared prior to the workshop.

Results and Conclusions: This summary information adds to the fuller understanding of the alveolar bone regenerative response with implications to reconstructive procedures for patient oral rehabilitation. The group collectively formulated and addressed critical questions based on each of the reviews in this consensus report to advance the field. The report concludes with identified areas of future research.


Original languageEnglish
Pages (from-to)6-11
Number of pages6
JournalJournal of Clinical Periodontology
Issue numberS21
Publication statusPublished - 18 Jun 2019


  • bone remodelling, bone turnover, osteogenesis, osteoimmunology, regenerative medicine, wound healing