Bioencapsulation by compression coating of probiotic bacteria for their protection in an acidic medium

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Bioencapsulation by compression coating of probiotic bacteria for their protection in an acidic medium. / Chan, E. S.; Zhang, Z.

In: Process Biochemistry, Vol. 40, No. 10, 10.2005, p. 3346-3351.

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@article{c0d57ec39e874995b2f0aecf46e549be,
title = "Bioencapsulation by compression coating of probiotic bacteria for their protection in an acidic medium",
abstract = "Compression coating was demonstrated as a novel encapsulation method for improving cell survival when cells were exposed to an acidic medium. Sodium alginate, which can form gels after being hydrated, has been exploited as the prime coating material. Probiotic cell containing powders were first compressed into a pellet, which was then encapsulated with the coating material by further compression. Results indicated significant improvement in survival of encapsulated cells when exposed to acidic media of pH 1.2 and 2. The encapsulated cells showed 104-105-fold increment in cell survival when compared to free cells under the test conditions. The formation of a hydrogel barrier by the compacted sodium alginate layer has shown to retard the permeation of the acidic fluid into the cells. This contributed to the enhanced cell survival. In addition, it could be deduced from in vitro tests that the release of encapsulated cells in the human digestive tract could occur near the end of the ileum and beginning of the colon. The mechanism of cell release is primarily due to the erosion of the alginate gel layer.",
keywords = "Acid protection, Compression coating, Encapsulation, Lactobacillus acidophilus, Probiotic, Sodium alginate",
author = "Chan, {E. S.} and Z. Zhang",
year = "2005",
month = oct,
doi = "10.1016/j.procbio.2005.03.001",
language = "English",
volume = "40",
pages = "3346--3351",
journal = "Process Biochemistry",
issn = "0032-9592",
publisher = "Elsevier",
number = "10",

}

RIS

TY - JOUR

T1 - Bioencapsulation by compression coating of probiotic bacteria for their protection in an acidic medium

AU - Chan, E. S.

AU - Zhang, Z.

PY - 2005/10

Y1 - 2005/10

N2 - Compression coating was demonstrated as a novel encapsulation method for improving cell survival when cells were exposed to an acidic medium. Sodium alginate, which can form gels after being hydrated, has been exploited as the prime coating material. Probiotic cell containing powders were first compressed into a pellet, which was then encapsulated with the coating material by further compression. Results indicated significant improvement in survival of encapsulated cells when exposed to acidic media of pH 1.2 and 2. The encapsulated cells showed 104-105-fold increment in cell survival when compared to free cells under the test conditions. The formation of a hydrogel barrier by the compacted sodium alginate layer has shown to retard the permeation of the acidic fluid into the cells. This contributed to the enhanced cell survival. In addition, it could be deduced from in vitro tests that the release of encapsulated cells in the human digestive tract could occur near the end of the ileum and beginning of the colon. The mechanism of cell release is primarily due to the erosion of the alginate gel layer.

AB - Compression coating was demonstrated as a novel encapsulation method for improving cell survival when cells were exposed to an acidic medium. Sodium alginate, which can form gels after being hydrated, has been exploited as the prime coating material. Probiotic cell containing powders were first compressed into a pellet, which was then encapsulated with the coating material by further compression. Results indicated significant improvement in survival of encapsulated cells when exposed to acidic media of pH 1.2 and 2. The encapsulated cells showed 104-105-fold increment in cell survival when compared to free cells under the test conditions. The formation of a hydrogel barrier by the compacted sodium alginate layer has shown to retard the permeation of the acidic fluid into the cells. This contributed to the enhanced cell survival. In addition, it could be deduced from in vitro tests that the release of encapsulated cells in the human digestive tract could occur near the end of the ileum and beginning of the colon. The mechanism of cell release is primarily due to the erosion of the alginate gel layer.

KW - Acid protection

KW - Compression coating

KW - Encapsulation

KW - Lactobacillus acidophilus

KW - Probiotic

KW - Sodium alginate

UR - http://www.scopus.com/inward/record.url?scp=27744598994&partnerID=8YFLogxK

U2 - 10.1016/j.procbio.2005.03.001

DO - 10.1016/j.procbio.2005.03.001

M3 - Article

AN - SCOPUS:27744598994

VL - 40

SP - 3346

EP - 3351

JO - Process Biochemistry

JF - Process Biochemistry

SN - 0032-9592

IS - 10

ER -