Binning metagenomic contigs by coverage and composition
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
Shotgun sequencing enables the reconstruction of genomes from complex microbial communities, but because assembly does not reconstruct entire genomes, it is necessary to bin genome fragments. Here we present CONCOCT, a new algorithm that combines sequence composition and coverage across multiple samples, to automatically cluster contigs into genomes. We demonstrate high recall and precision on artificial as well as real human gut metagenome data sets.
|Number of pages||3|
|Publication status||Published - Nov 2014|
- Algorithms, Bifidobacterium, Contig Mapping, Escherichia coli K12, Feces, Gastrointestinal Tract, Genome, Bacterial, Humans, Metagenome, Metagenomics, Microbiota, Sequence Analysis, DNA, Shiga-Toxigenic Escherichia coli, Software