Bilateral retinal vasculitis in a patient with systemic lupus erythematosus and its remission with rituximab therapy

Richard Hickman, Alastair Denniston, Chee Yee, Veronica Toescu, Philip Murray, Caroline Gordon

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Severe retinal vasculitis is a rare, but potentially blinding, complication of patients with systemic lupus erythematosus (SLE). We describe here the first reported case of treating severe bilateral SLE-associated retinal vasculitis with the anti-CD20 monoclonal antibody rituximab, a drug which has established its role in rheumatoid arthritis and has shown promise in case series for the treatment of severe SLE that is unresponsive to other therapies. This case suggests that rituximab-induced B-cell depletion may provide an important new therapeutic option for refractory cases of this devastating ocular complication.
Original languageEnglish
JournalLupus
DOIs
Publication statusPublished - 9 Nov 2009

Keywords

  • SYSTEMIC LUPUS ERYTHEMATOSUS
  • rituximab
  • retinal vasculitis
  • lupus
  • DISEASE ACTIVITY
  • CORONARY HEART DISEASE
  • therapy
  • B-cell depletion
  • RISK FACTORS

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