bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in the zebrafish.

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

Hematopoiesis maintains the entire blood system, and dysregulation of this process can lead to malignancies (leukemia), immunodeficiencies or red blood cell diseases (anemia, polycythemia vera). We took advantage of the zebrafish model that shares most of the genetic program involved in hematopoiesis with mammals to characterize a new gene of unknown function, si:ch73-299h12.2, which is expressed in the erythroid lineage during primitive, definitive and adult hematopoiesis. This gene, required during primitive and definitive erythropoiesis, encodes a C2H2 zinc-finger protein that inhibits BMP signaling. We therefore named this gene blood-inducing factor 1 and BMP inhibitory factor 1 ( bif1). We identified a bif1 ortholog in Sinocyclocheilus rhinocerous, another fish, and in the mouse genome. Both genes also inhibit BMP signaling when overexpressed in zebrafish. In conclusion, we have deorphanized a new zebrafish gene of unknown function: bif1 codes for a zinc-finger protein that inhibits BMP signaling and also regulates primitive erythropoiesis and definitive hematopoiesis.

Bibliographic note

© 2019. Published by The Company of Biologists Ltd.

Details

Original languageEnglish
JournalDevelopment
Volume146
Issue number6
Early online date5 Mar 2019
Publication statusPublished - 21 Mar 2019

Keywords

  • zebrafish, erythropoiesis, definitive hematopoiesis, hematopoietic stem cells, BMP signalling, zinc finger proteins