Bi-aryl rotation in phenyl-dihydroimidazoquinoline catalysts for kinetic resolution of arylalkyl carbinols
Research output: Contribution to journal › Article
Colleges, School and Institutes
- State Key Laboratory of Bioreactor Engineering & Department of Chemistry, East China University of Science and Technology, Shanghai 200237, China.
- Shanghai Key Laboratory of New Drug Design & School of Pharmacy, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, China.
- School of Chemistry; University of Birmingham; Edgbaston Birmingham B15 2TT UK
Chiral nucleophilic catalysts, 6-aryl-phenyl-dihydroimidazoquinolines (PIQs), were designed, synthesised and applied to the kinetic resolution of arylalkyl carbinols with very high selectivity (S) factors (up to 530). Density functional theory calculations indicate that multiple noncovalent interactions play a key role in chiral recognition between 6-aryl-PIQ catalysts and chiral secondary alcohol substrates.
|Number of pages||5|
|Journal||Catalysis Science and Technology|
|Publication status||Published - 1 Jan 2014|