Beyond water homeostasis: diverse functional roles of mammalian aquaporins

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Beyond water homeostasis : diverse functional roles of mammalian aquaporins. / Kitchen, Philip; Day, Rebecca E.; Salman, Mootaz M.; Conner, Matthew T.; Bill, Roslyn M.; Conner, Alex C.

In: Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1850, No. 12, 12.2015, p. 2410-2421.

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@article{9d47d9fdebf044cc9ceb92785f722d6f,
title = "Beyond water homeostasis: diverse functional roles of mammalian aquaporins",
abstract = "BackgroundAquaporin (AQP) water channels are best known as passive transporters of water that are vital for water homeostasis.Scope of reviewAQP knockout studies in whole animals and cultured cells, along with naturally occurring human mutations suggest that the transport of neutral solutes through AQPs has important physiological roles. Emerging biophysical evidence suggests that AQPs may also facilitate gas (CO2) and cation transport. AQPs may be involved in cell signalling for volume regulation and controlling the subcellular localization of other proteins by forming macromolecular complexes. This review examines the evidence for these diverse functions of AQPs as well their physiological relevance.Major conclusionsAs well as being crucial for water homeostasis, AQPs are involved in physiologically important transport of molecules other than water, regulation of surface expression of other membrane proteins, cell adhesion, and signalling in cell volume regulation.General significanceElucidating the full range of functional roles of AQPs beyond the passive conduction of water will improve our understanding of mammalian physiology in health and disease. The functional variety of AQPs makes them an exciting drug target and could provide routes to a range of novel therapies.",
keywords = "Aquaporin, Solute transport, ion transport, membrane trafficking, cell volume , regulation",
author = "Philip Kitchen and Day, {Rebecca E.} and Salman, {Mootaz M.} and Conner, {Matthew T.} and Bill, {Roslyn M.} and Conner, {Alex C.}",
year = "2015",
month = dec
doi = "10.1016/j.bbagen.2015.08.023",
language = "English",
volume = "1850",
pages = "2410--2421",
journal = "Biochimica et Biophysica Acta (BBA) - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - Beyond water homeostasis

T2 - diverse functional roles of mammalian aquaporins

AU - Kitchen, Philip

AU - Day, Rebecca E.

AU - Salman, Mootaz M.

AU - Conner, Matthew T.

AU - Bill, Roslyn M.

AU - Conner, Alex C.

PY - 2015/12

Y1 - 2015/12

N2 - BackgroundAquaporin (AQP) water channels are best known as passive transporters of water that are vital for water homeostasis.Scope of reviewAQP knockout studies in whole animals and cultured cells, along with naturally occurring human mutations suggest that the transport of neutral solutes through AQPs has important physiological roles. Emerging biophysical evidence suggests that AQPs may also facilitate gas (CO2) and cation transport. AQPs may be involved in cell signalling for volume regulation and controlling the subcellular localization of other proteins by forming macromolecular complexes. This review examines the evidence for these diverse functions of AQPs as well their physiological relevance.Major conclusionsAs well as being crucial for water homeostasis, AQPs are involved in physiologically important transport of molecules other than water, regulation of surface expression of other membrane proteins, cell adhesion, and signalling in cell volume regulation.General significanceElucidating the full range of functional roles of AQPs beyond the passive conduction of water will improve our understanding of mammalian physiology in health and disease. The functional variety of AQPs makes them an exciting drug target and could provide routes to a range of novel therapies.

AB - BackgroundAquaporin (AQP) water channels are best known as passive transporters of water that are vital for water homeostasis.Scope of reviewAQP knockout studies in whole animals and cultured cells, along with naturally occurring human mutations suggest that the transport of neutral solutes through AQPs has important physiological roles. Emerging biophysical evidence suggests that AQPs may also facilitate gas (CO2) and cation transport. AQPs may be involved in cell signalling for volume regulation and controlling the subcellular localization of other proteins by forming macromolecular complexes. This review examines the evidence for these diverse functions of AQPs as well their physiological relevance.Major conclusionsAs well as being crucial for water homeostasis, AQPs are involved in physiologically important transport of molecules other than water, regulation of surface expression of other membrane proteins, cell adhesion, and signalling in cell volume regulation.General significanceElucidating the full range of functional roles of AQPs beyond the passive conduction of water will improve our understanding of mammalian physiology in health and disease. The functional variety of AQPs makes them an exciting drug target and could provide routes to a range of novel therapies.

KW - Aquaporin

KW - Solute transport

KW - ion transport

KW - membrane trafficking

KW - cell volume

KW - regulation

U2 - 10.1016/j.bbagen.2015.08.023

DO - 10.1016/j.bbagen.2015.08.023

M3 - Article

VL - 1850

SP - 2410

EP - 2421

JO - Biochimica et Biophysica Acta (BBA) - General Subjects

JF - Biochimica et Biophysica Acta (BBA) - General Subjects

SN - 0304-4165

IS - 12

ER -