Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

Haobo Ge; Patrick J. Riss; Vincenzo Mirabello; David G. Calatayud; Stephen E. Flower; Rory L. Arrowsmith; Tim D. Fryer; Young Hong; Steve Sawiak; Robert M.J. Jacobs; Stanley W. Botchway; Rex M. Tyrrell; Tony D. James; John S. Fossey; Jonathan R. Dilworth; Franklin I. Aigbirhio; Sofia I. Pascu

doi:10.1016/j.chempr.2017.06.013

Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

Haobo Ge, Patrick J. Riss, Vincenzo Mirabello, David G. Calatayud, Stephen E. Flower, Rory L. Arrowsmith, Tim D. Fryer, Young Hong, Steve Sawiak, Robert M.J. Jacobs, Stanley W. Botchway, Rex M. Tyrrell, Tony D. James, John S. Fossey, Jonathan R. Dilworth, Franklin I. Aigbirhio^*, Sofia I. Pascu

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Hybrid materials based on supramolecularly assembled single-walled carbon nanotubes (SWNTs) are generated for positron emission tomography (PET), magnetic resonance imaging, and fluorescence imaging. The all-in-one imaging probe allows quantitative imaging from subcellular resolution to whole tissue regions. The SWNTs can be exposed to aqueous solutions of non-radioactive and radioactive metal salts in the presence of fullerenes and β-D-glucan. Encapsulating ⁶⁴Cu ions achieves a minimum of 69% incorporation of radiochemical. The results suggest that this method can be extended to other metal ions of medical relevance, such as zirconium(IV)-89 or rhenium(VII)-188, which are used for medical imaging or radiotherapy, respectively. The in vivo uptake of ⁶⁴Cu(II)@SWNT@β-D-glucan in Wistar rats allows the investigation of organ biodistribution by microPET. Radioactivity rapidly accumulates predominantly in the lungs and myocardium with peak uptakes of 4.8 ± 0.9 standardized uptake value. Furthermore, such materials are fully traceable in cells by multiphoton fluorescence lifetime imaging with near-infrared excitation (910 nm).

Original language	English
Pages (from-to)	437-460
Number of pages	24
Journal	Chem
Volume	3
Issue number	3
Early online date	31 Aug 2017
DOIs	https://doi.org/10.1016/j.chempr.2017.06.013
Publication status	Published - 14 Sept 2017

Keywords

carbon nanotubes
copper-64
directed and self-assembly
fluorescence microscopy
nano-radiochemistry
nanohybrid materials
positron emission tomography
supramolecular chemistry

ASJC Scopus subject areas

General Chemistry
Biochemistry
Environmental Chemistry
General Chemical Engineering
Biochemistry, medical
Materials Chemistry

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10.1016/j.chempr.2017.06.013Licence: Creative Commons: Attribution (CC BY)

https://www.sciencedirect.com/science/article/pii/S2451929417302735Licence: Creative Commons: Attribution (CC BY)

Boronic Acids for Dye Sensitised Solar Cells
Fossey, J.
Engineering & Physical Science Research Council
23/04/12 → 22/04/14
Project: Research

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Ge, H., Riss, P. J., Mirabello, V., Calatayud, D. G., Flower, S. E., Arrowsmith, R. L., Fryer, T. D., Hong, Y., Sawiak, S., Jacobs, R. M. J., Botchway, S. W., Tyrrell, R. M., James, T. D., Fossey, J. S., Dilworth, J. R., Aigbirhio, F. I., & Pascu, S. I. (2017). Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo. Chem, 3(3), 437-460. https://doi.org/10.1016/j.chempr.2017.06.013

@article{0d2679e4739740ab906783ec82efb3f6,

title = "Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo",

abstract = "Hybrid materials based on supramolecularly assembled single-walled carbon nanotubes (SWNTs) are generated for positron emission tomography (PET), magnetic resonance imaging, and fluorescence imaging. The all-in-one imaging probe allows quantitative imaging from subcellular resolution to whole tissue regions. The SWNTs can be exposed to aqueous solutions of non-radioactive and radioactive metal salts in the presence of fullerenes and β-D-glucan. Encapsulating 64Cu ions achieves a minimum of 69% incorporation of radiochemical. The results suggest that this method can be extended to other metal ions of medical relevance, such as zirconium(IV)-89 or rhenium(VII)-188, which are used for medical imaging or radiotherapy, respectively. The in vivo uptake of 64Cu(II)@SWNT@β-D-glucan in Wistar rats allows the investigation of organ biodistribution by microPET. Radioactivity rapidly accumulates predominantly in the lungs and myocardium with peak uptakes of 4.8 ± 0.9 standardized uptake value. Furthermore, such materials are fully traceable in cells by multiphoton fluorescence lifetime imaging with near-infrared excitation (910 nm).",

keywords = "carbon nanotubes, copper-64, directed and self-assembly, fluorescence microscopy, nano-radiochemistry, nanohybrid materials, positron emission tomography, supramolecular chemistry",

author = "Haobo Ge and Riss, {Patrick J.} and Vincenzo Mirabello and Calatayud, {David G.} and Flower, {Stephen E.} and Arrowsmith, {Rory L.} and Fryer, {Tim D.} and Young Hong and Steve Sawiak and Jacobs, {Robert M.J.} and Botchway, {Stanley W.} and Tyrrell, {Rex M.} and James, {Tony D.} and Fossey, {John S.} and Dilworth, {Jonathan R.} and Aigbirhio, {Franklin I.} and Pascu, {Sofia I.}",

year = "2017",

month = sep,

day = "14",

doi = "10.1016/j.chempr.2017.06.013",

language = "English",

volume = "3",

pages = "437--460",

journal = "Chem",

issn = "2451-9308",

publisher = "Elsevier",

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Ge, H, Riss, PJ, Mirabello, V, Calatayud, DG, Flower, SE, Arrowsmith, RL, Fryer, TD, Hong, Y, Sawiak, S, Jacobs, RMJ, Botchway, SW, Tyrrell, RM, James, TD, Fossey, JS, Dilworth, JR, Aigbirhio, FI & Pascu, SI 2017, 'Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo', Chem, vol. 3, no. 3, pp. 437-460. https://doi.org/10.1016/j.chempr.2017.06.013

TY - JOUR

T1 - Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

AU - Ge, Haobo

AU - Riss, Patrick J.

AU - Mirabello, Vincenzo

AU - Calatayud, David G.

AU - Flower, Stephen E.

AU - Arrowsmith, Rory L.

AU - Fryer, Tim D.

AU - Hong, Young

AU - Sawiak, Steve

AU - Jacobs, Robert M.J.

AU - Botchway, Stanley W.

AU - Tyrrell, Rex M.

AU - James, Tony D.

AU - Fossey, John S.

AU - Dilworth, Jonathan R.

AU - Aigbirhio, Franklin I.

AU - Pascu, Sofia I.

PY - 2017/9/14

Y1 - 2017/9/14

N2 - Hybrid materials based on supramolecularly assembled single-walled carbon nanotubes (SWNTs) are generated for positron emission tomography (PET), magnetic resonance imaging, and fluorescence imaging. The all-in-one imaging probe allows quantitative imaging from subcellular resolution to whole tissue regions. The SWNTs can be exposed to aqueous solutions of non-radioactive and radioactive metal salts in the presence of fullerenes and β-D-glucan. Encapsulating 64Cu ions achieves a minimum of 69% incorporation of radiochemical. The results suggest that this method can be extended to other metal ions of medical relevance, such as zirconium(IV)-89 or rhenium(VII)-188, which are used for medical imaging or radiotherapy, respectively. The in vivo uptake of 64Cu(II)@SWNT@β-D-glucan in Wistar rats allows the investigation of organ biodistribution by microPET. Radioactivity rapidly accumulates predominantly in the lungs and myocardium with peak uptakes of 4.8 ± 0.9 standardized uptake value. Furthermore, such materials are fully traceable in cells by multiphoton fluorescence lifetime imaging with near-infrared excitation (910 nm).

AB - Hybrid materials based on supramolecularly assembled single-walled carbon nanotubes (SWNTs) are generated for positron emission tomography (PET), magnetic resonance imaging, and fluorescence imaging. The all-in-one imaging probe allows quantitative imaging from subcellular resolution to whole tissue regions. The SWNTs can be exposed to aqueous solutions of non-radioactive and radioactive metal salts in the presence of fullerenes and β-D-glucan. Encapsulating 64Cu ions achieves a minimum of 69% incorporation of radiochemical. The results suggest that this method can be extended to other metal ions of medical relevance, such as zirconium(IV)-89 or rhenium(VII)-188, which are used for medical imaging or radiotherapy, respectively. The in vivo uptake of 64Cu(II)@SWNT@β-D-glucan in Wistar rats allows the investigation of organ biodistribution by microPET. Radioactivity rapidly accumulates predominantly in the lungs and myocardium with peak uptakes of 4.8 ± 0.9 standardized uptake value. Furthermore, such materials are fully traceable in cells by multiphoton fluorescence lifetime imaging with near-infrared excitation (910 nm).

KW - carbon nanotubes

KW - copper-64

KW - directed and self-assembly

KW - fluorescence microscopy

KW - nano-radiochemistry

KW - nanohybrid materials

KW - positron emission tomography

KW - supramolecular chemistry

UR - http://www.scopus.com/inward/record.url?scp=85029488808&partnerID=8YFLogxK

U2 - 10.1016/j.chempr.2017.06.013

DO - 10.1016/j.chempr.2017.06.013

M3 - Article

AN - SCOPUS:85029488808

SN - 2451-9308

VL - 3

SP - 437

EP - 460

JO - Chem

JF - Chem

IS - 3

ER -

Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

Abstract

Keywords

ASJC Scopus subject areas

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