Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

Vanessa L Cropley; Ashleigh Lin; Renate L E P Reniers; Stephen J Wood; Barnaby Nelson; Alison R Yung; Cali F Bartholomeusz; Paul Klauser; Dennis Velakoulis; Patrick McGorry; Christos Pantelis

doi:10.1016/j.schres.2015.05.014

Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

Vanessa L Cropley, Ashleigh Lin, Renate L E P Reniers, Stephen J Wood, Barnaby Nelson, Alison R Yung, Cali F Bartholomeusz, Paul Klauser, Dennis Velakoulis, Patrick McGorry, Christos Pantelis

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Abstract

INTRODUCTION: Two thirds of individuals identified as ultra-high risk (UHR) for psychosis do not transition to psychosis over the medium to long-term (non-transition; UHR-NT). Nevertheless, many of these individuals have persistent attenuated psychotic symptoms (APS). The current study examined whether there were differences in baseline grey matter volume (i.e. at initial identification as UHR) in UHR-NT individuals whom had APS compared to those without APS (No-APS) at medium to long-term follow-up.

METHODS: Participants were help-seeking individuals who were identified as being at UHR for psychosis between 2 and 12years previously (mean=7.5). The sample consisted of 109 participants who underwent a Magnetic Resonance Imaging scan at baseline and who had not been observed to develop a psychotic disorder over the follow-up period (UHR-NT). Using voxel-based morphometry, baseline grey matter volume (GMV) was compared between participants with (N=30) and without (N=79) APS at follow-up.

RESULTS: At baseline, the APS and No-APS groups were clinically indistinguishable. At follow-up, the APS group had significantly worse symptoms and impaired functioning. Individuals with APS had reduced baseline GMV in frontal, temporal, posterior and cingulate regions compared to those without APS at follow-up. Reduced GMV was associated with more severe positive, negative and depressive symptoms and lower global functioning in the combined UHR-NT cohort. These associations were independent of later APS outcome.

DISCUSSION: This study found that differences in regional GMV are discernible at an early stage of UHR and may be specific to individuals who have APS and psychopathology at follow-up. Our findings suggest that lower GMV at baseline may confer neurobiological risk for later APS and/or increased psychopathology while the absence of these structural abnormalities might be protective.

Original language	English
Pages (from-to)	152-158
Number of pages	7
Journal	Schizophrenia Research
Volume	173
Issue number	3
Early online date	29 May 2015
DOIs	https://doi.org/10.1016/j.schres.2015.05.014
Publication status	Published - Jun 2016

Bibliographical note

Keywords

Ultra-high risk
Psychosis
Attenuated psychotic symptoms
Non-transition
Imaging
Grey matter volume

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Cropley, V. L., Lin, A., Reniers, R. L. E. P., Wood, S. J., Nelson, B., Yung, A. R., Bartholomeusz, C. F., Klauser, P., Velakoulis, D., McGorry, P., & Pantelis, C. (2016). Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up. Schizophrenia Research, 173(3), 152-158. Advance online publication. https://doi.org/10.1016/j.schres.2015.05.014

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title = "Baseline grey matter volume of non-transitioned {"}ultra high risk{"} for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up",

abstract = "INTRODUCTION: Two thirds of individuals identified as ultra-high risk (UHR) for psychosis do not transition to psychosis over the medium to long-term (non-transition; UHR-NT). Nevertheless, many of these individuals have persistent attenuated psychotic symptoms (APS). The current study examined whether there were differences in baseline grey matter volume (i.e. at initial identification as UHR) in UHR-NT individuals whom had APS compared to those without APS (No-APS) at medium to long-term follow-up.METHODS: Participants were help-seeking individuals who were identified as being at UHR for psychosis between 2 and 12years previously (mean=7.5). The sample consisted of 109 participants who underwent a Magnetic Resonance Imaging scan at baseline and who had not been observed to develop a psychotic disorder over the follow-up period (UHR-NT). Using voxel-based morphometry, baseline grey matter volume (GMV) was compared between participants with (N=30) and without (N=79) APS at follow-up.RESULTS: At baseline, the APS and No-APS groups were clinically indistinguishable. At follow-up, the APS group had significantly worse symptoms and impaired functioning. Individuals with APS had reduced baseline GMV in frontal, temporal, posterior and cingulate regions compared to those without APS at follow-up. Reduced GMV was associated with more severe positive, negative and depressive symptoms and lower global functioning in the combined UHR-NT cohort. These associations were independent of later APS outcome.DISCUSSION: This study found that differences in regional GMV are discernible at an early stage of UHR and may be specific to individuals who have APS and psychopathology at follow-up. Our findings suggest that lower GMV at baseline may confer neurobiological risk for later APS and/or increased psychopathology while the absence of these structural abnormalities might be protective.",

keywords = "Ultra-high risk, Psychosis, Attenuated psychotic symptoms, Non-transition, Imaging, Grey matter volume",

author = "Cropley, {Vanessa L} and Ashleigh Lin and Reniers, {Renate L E P} and Wood, {Stephen J} and Barnaby Nelson and Yung, {Alison R} and Bartholomeusz, {Cali F} and Paul Klauser and Dennis Velakoulis and Patrick McGorry and Christos Pantelis",

year = "2016",

month = jun,

doi = "10.1016/j.schres.2015.05.014",

language = "English",

volume = "173",

pages = "152--158",

journal = "Schizophrenia Research",

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Cropley, VL, Lin, A, Reniers, RLEP , Wood, SJ, Nelson, B, Yung, AR, Bartholomeusz, CF, Klauser, P, Velakoulis, D, McGorry, P & Pantelis, C 2016, 'Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up', Schizophrenia Research, vol. 173, no. 3, pp. 152-158. https://doi.org/10.1016/j.schres.2015.05.014

TY - JOUR

T1 - Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

AU - Cropley, Vanessa L

AU - Lin, Ashleigh

AU - Reniers, Renate L E P

AU - Wood, Stephen J

AU - Nelson, Barnaby

AU - Yung, Alison R

AU - Bartholomeusz, Cali F

AU - Klauser, Paul

AU - Velakoulis, Dennis

AU - McGorry, Patrick

AU - Pantelis, Christos

PY - 2016/6

Y1 - 2016/6

N2 - INTRODUCTION: Two thirds of individuals identified as ultra-high risk (UHR) for psychosis do not transition to psychosis over the medium to long-term (non-transition; UHR-NT). Nevertheless, many of these individuals have persistent attenuated psychotic symptoms (APS). The current study examined whether there were differences in baseline grey matter volume (i.e. at initial identification as UHR) in UHR-NT individuals whom had APS compared to those without APS (No-APS) at medium to long-term follow-up.METHODS: Participants were help-seeking individuals who were identified as being at UHR for psychosis between 2 and 12years previously (mean=7.5). The sample consisted of 109 participants who underwent a Magnetic Resonance Imaging scan at baseline and who had not been observed to develop a psychotic disorder over the follow-up period (UHR-NT). Using voxel-based morphometry, baseline grey matter volume (GMV) was compared between participants with (N=30) and without (N=79) APS at follow-up.RESULTS: At baseline, the APS and No-APS groups were clinically indistinguishable. At follow-up, the APS group had significantly worse symptoms and impaired functioning. Individuals with APS had reduced baseline GMV in frontal, temporal, posterior and cingulate regions compared to those without APS at follow-up. Reduced GMV was associated with more severe positive, negative and depressive symptoms and lower global functioning in the combined UHR-NT cohort. These associations were independent of later APS outcome.DISCUSSION: This study found that differences in regional GMV are discernible at an early stage of UHR and may be specific to individuals who have APS and psychopathology at follow-up. Our findings suggest that lower GMV at baseline may confer neurobiological risk for later APS and/or increased psychopathology while the absence of these structural abnormalities might be protective.

AB - INTRODUCTION: Two thirds of individuals identified as ultra-high risk (UHR) for psychosis do not transition to psychosis over the medium to long-term (non-transition; UHR-NT). Nevertheless, many of these individuals have persistent attenuated psychotic symptoms (APS). The current study examined whether there were differences in baseline grey matter volume (i.e. at initial identification as UHR) in UHR-NT individuals whom had APS compared to those without APS (No-APS) at medium to long-term follow-up.METHODS: Participants were help-seeking individuals who were identified as being at UHR for psychosis between 2 and 12years previously (mean=7.5). The sample consisted of 109 participants who underwent a Magnetic Resonance Imaging scan at baseline and who had not been observed to develop a psychotic disorder over the follow-up period (UHR-NT). Using voxel-based morphometry, baseline grey matter volume (GMV) was compared between participants with (N=30) and without (N=79) APS at follow-up.RESULTS: At baseline, the APS and No-APS groups were clinically indistinguishable. At follow-up, the APS group had significantly worse symptoms and impaired functioning. Individuals with APS had reduced baseline GMV in frontal, temporal, posterior and cingulate regions compared to those without APS at follow-up. Reduced GMV was associated with more severe positive, negative and depressive symptoms and lower global functioning in the combined UHR-NT cohort. These associations were independent of later APS outcome.DISCUSSION: This study found that differences in regional GMV are discernible at an early stage of UHR and may be specific to individuals who have APS and psychopathology at follow-up. Our findings suggest that lower GMV at baseline may confer neurobiological risk for later APS and/or increased psychopathology while the absence of these structural abnormalities might be protective.

KW - Ultra-high risk

KW - Psychosis

KW - Attenuated psychotic symptoms

KW - Non-transition

KW - Imaging

KW - Grey matter volume

U2 - 10.1016/j.schres.2015.05.014

DO - 10.1016/j.schres.2015.05.014

M3 - Article

C2 - 26032566

SN - 0920-9964

VL - 173

SP - 152

EP - 158

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 3

ER -

Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

Abstract

Bibliographical note

Keywords

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