Bacterial flagellar diversity in the post-genomic era
Research output: Contribution to journal › Review article
Colleges, School and Institutes
Flagellar biosynthesis has been studied most thoroughly in laboratory strains of Escherichia coli and Salmonella enterica. However, genome sequencing has uncovered flagellar loci in distantly related bacteria. We have used homology searches to determine how far the E. coli/S. enterica paradigm can be generalised to other flagellar systems. Numerous previously unrecognized homologues of flagellar components were discovered, including novel FIgM, FIgN, FliK and FliO homologues. Homology was found between the FIiK proteins and a molecular ruler, YscP, from a virulence-associated type-III secretion system. Also described is a new family of flagellar proteins, the FIhX proteins, which resemble the cytoplasmic domain of FIhB.
|Number of pages||7|
|Journal||Trends in Microbiology|
|Publication status||Published - 1 Apr 2005|