Bacterial flagellar diversity in the post-genomic era

Research output: Contribution to journalReview article

Colleges, School and Institutes

Abstract

Flagellar biosynthesis has been studied most thoroughly in laboratory strains of Escherichia coli and Salmonella enterica. However, genome sequencing has uncovered flagellar loci in distantly related bacteria. We have used homology searches to determine how far the E. coli/S. enterica paradigm can be generalised to other flagellar systems. Numerous previously unrecognized homologues of flagellar components were discovered, including novel FIgM, FIgN, FliK and FliO homologues. Homology was found between the FIiK proteins and a molecular ruler, YscP, from a virulence-associated type-III secretion system. Also described is a new family of flagellar proteins, the FIhX proteins, which resemble the cytoplasmic domain of FIhB.

Details

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalTrends in Microbiology
Volume13
Issue number4
Publication statusPublished - 1 Apr 2005