Bacterial FHA domains: neglected players in the phospho-threonine signalling game?

Research output: Contribution to journalArticle

Colleges, School and Institutes

Abstract

Forkhead-associated (FHA) domains bind phospho-threonine peptides and are known to mediate phosphorylation-dependent protein-protein interactions in a variety of eukaryotic settings. However, their role in bacterial physiology and signalling has been largely neglected. We have surveyed bacterial FHA domains and discovered that they are implicated in many bacterial processes, including regulation of cell shape, type III secretion, sporulation, pathogenic and symbiotic host-bacterium interactions, carbohydrate storage and transport, signal transduction and ethambutol resistance. The way is now open to identify the targets of each FHA domain, and their roles in cellular physiology, and perhaps even to develop novel FHA-blocking antibacterial agents.

Details

Original languageEnglish
Pages (from-to)556-63
Number of pages8
JournalTrends in Microbiology
Volume10
Issue number12
Publication statusPublished - 1 Dec 2002