Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes

Research output: Contribution to journalArticle

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Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes. / Lui, Leong T; Xue, Xuan; Sui, Cheng; Brown, Alan; Pritchard, David I; Halliday, Nigel; Winzer, Klaus; Howdle, Steven M; Fernandez-Trillo, Francisco; Krasnogor, Natalio; Alexander, Cameron.

In: Nature Chemistry, Vol. 5, No. 12, 12.2013, p. 1058-65.

Research output: Contribution to journalArticle

Harvard

Lui, LT, Xue, X, Sui, C, Brown, A, Pritchard, DI, Halliday, N, Winzer, K, Howdle, SM, Fernandez-Trillo, F, Krasnogor, N & Alexander, C 2013, 'Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes', Nature Chemistry, vol. 5, no. 12, pp. 1058-65. https://doi.org/10.1038/nchem.1793

APA

Lui, L. T., Xue, X., Sui, C., Brown, A., Pritchard, D. I., Halliday, N., Winzer, K., Howdle, S. M., Fernandez-Trillo, F., Krasnogor, N., & Alexander, C. (2013). Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes. Nature Chemistry, 5(12), 1058-65. https://doi.org/10.1038/nchem.1793

Vancouver

Author

Lui, Leong T ; Xue, Xuan ; Sui, Cheng ; Brown, Alan ; Pritchard, David I ; Halliday, Nigel ; Winzer, Klaus ; Howdle, Steven M ; Fernandez-Trillo, Francisco ; Krasnogor, Natalio ; Alexander, Cameron. / Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes. In: Nature Chemistry. 2013 ; Vol. 5, No. 12. pp. 1058-65.

Bibtex

@article{172a61e4c3b74913a94ac03ffa4f6a62,
title = "Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes",
abstract = "Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one method by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can interfere with bacterial adhesion or the chemical reactions used for quorum sensing are therefore a potential means to control bacterial population responses. Here, we report how polymeric 'bacteria sequestrants', designed to bind to bacteria through electrostatic interactions and therefore inhibit bacterial adhesion to surfaces, induce the expression of quorum-sensing-controlled phenotypes as a consequence of cell clustering. A combination of polymer and analytical chemistry, biological assays and computational modelling has been used to characterize the feedback between bacteria clustering and quorum sensing signalling. We have also derived design principles and chemical strategies for controlling bacterial behaviour at the population level.",
author = "Lui, {Leong T} and Xuan Xue and Cheng Sui and Alan Brown and Pritchard, {David I} and Nigel Halliday and Klaus Winzer and Howdle, {Steven M} and Francisco Fernandez-Trillo and Natalio Krasnogor and Cameron Alexander",
year = "2013",
month = dec,
doi = "10.1038/nchem.1793",
language = "English",
volume = "5",
pages = "1058--65",
journal = "Nature Chemistry",
issn = "1755-4330",
publisher = "Nature Publishing Group",
number = "12",

}

RIS

TY - JOUR

T1 - Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes

AU - Lui, Leong T

AU - Xue, Xuan

AU - Sui, Cheng

AU - Brown, Alan

AU - Pritchard, David I

AU - Halliday, Nigel

AU - Winzer, Klaus

AU - Howdle, Steven M

AU - Fernandez-Trillo, Francisco

AU - Krasnogor, Natalio

AU - Alexander, Cameron

PY - 2013/12

Y1 - 2013/12

N2 - Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one method by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can interfere with bacterial adhesion or the chemical reactions used for quorum sensing are therefore a potential means to control bacterial population responses. Here, we report how polymeric 'bacteria sequestrants', designed to bind to bacteria through electrostatic interactions and therefore inhibit bacterial adhesion to surfaces, induce the expression of quorum-sensing-controlled phenotypes as a consequence of cell clustering. A combination of polymer and analytical chemistry, biological assays and computational modelling has been used to characterize the feedback between bacteria clustering and quorum sensing signalling. We have also derived design principles and chemical strategies for controlling bacterial behaviour at the population level.

AB - Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one method by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can interfere with bacterial adhesion or the chemical reactions used for quorum sensing are therefore a potential means to control bacterial population responses. Here, we report how polymeric 'bacteria sequestrants', designed to bind to bacteria through electrostatic interactions and therefore inhibit bacterial adhesion to surfaces, induce the expression of quorum-sensing-controlled phenotypes as a consequence of cell clustering. A combination of polymer and analytical chemistry, biological assays and computational modelling has been used to characterize the feedback between bacteria clustering and quorum sensing signalling. We have also derived design principles and chemical strategies for controlling bacterial behaviour at the population level.

U2 - 10.1038/nchem.1793

DO - 10.1038/nchem.1793

M3 - Article

C2 - 24256871

VL - 5

SP - 1058

EP - 1065

JO - Nature Chemistry

JF - Nature Chemistry

SN - 1755-4330

IS - 12

ER -