B cell depletion in autoimmune diabetes: insights from murine models.

Research output: Contribution to journalArticle

Standard

B cell depletion in autoimmune diabetes: insights from murine models. / Chamberlain, Jayne; Attridge, Kesley; Wang, C; Ryan, Gavin; Walker, Lucy.

In: Expert Opinion on Therapeutic Targets, Vol. 15, No. 6, 01.06.2011, p. 703-14.

Research output: Contribution to journalArticle

Harvard

APA

Vancouver

Author

Bibtex

@article{f4b38f75110749419acda8e1b00a4752,
title = "B cell depletion in autoimmune diabetes: insights from murine models.",
abstract = "Introduction: The incidence of type 1 diabetes (T1D) is rising for reasons that largely elude us. New strategies aimed at halting the disease process are needed. One type of immune cell thought to contribute to T1D is the B lymphocyte. The first Phase II trial of B cell depletion in new onset T1D patients indicated that this slowed the destruction of insulin-producing pancreatic beta cells. The mechanistic basis of the beneficial effects remains unclear. Areas covered: Studies of B cell depletion and deficiency in animal models of T1D. How B cells can influence T cell-dependent autoimmune diabetes in animal models. The heterogeneity of B cell populations and current evidence for the potential contribution of specific B cell subsets to diabetes, with emphasis on marginal zone B cells and B1 B cells. Expert opinion: B cells can influence the T cell response to islet antigens and B cell depletion or genetic deficiency is associated with decreased insulitis in animal models. New evidence suggests that B1 cells may contribute to diabetes pathogenesis. A better understanding of the roles of individual B cell subsets in disease will permit fine-tuning of therapeutic strategies to modify these populations.",
author = "Jayne Chamberlain and Kesley Attridge and C Wang and Gavin Ryan and Lucy Walker",
year = "2011",
month = jun,
day = "1",
doi = "10.1517/14728222.2011.561320",
language = "English",
volume = "15",
pages = "703--14",
journal = "Expert Opinion on Therapeutic Targets",
issn = "1472-8222",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - B cell depletion in autoimmune diabetes: insights from murine models.

AU - Chamberlain, Jayne

AU - Attridge, Kesley

AU - Wang, C

AU - Ryan, Gavin

AU - Walker, Lucy

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Introduction: The incidence of type 1 diabetes (T1D) is rising for reasons that largely elude us. New strategies aimed at halting the disease process are needed. One type of immune cell thought to contribute to T1D is the B lymphocyte. The first Phase II trial of B cell depletion in new onset T1D patients indicated that this slowed the destruction of insulin-producing pancreatic beta cells. The mechanistic basis of the beneficial effects remains unclear. Areas covered: Studies of B cell depletion and deficiency in animal models of T1D. How B cells can influence T cell-dependent autoimmune diabetes in animal models. The heterogeneity of B cell populations and current evidence for the potential contribution of specific B cell subsets to diabetes, with emphasis on marginal zone B cells and B1 B cells. Expert opinion: B cells can influence the T cell response to islet antigens and B cell depletion or genetic deficiency is associated with decreased insulitis in animal models. New evidence suggests that B1 cells may contribute to diabetes pathogenesis. A better understanding of the roles of individual B cell subsets in disease will permit fine-tuning of therapeutic strategies to modify these populations.

AB - Introduction: The incidence of type 1 diabetes (T1D) is rising for reasons that largely elude us. New strategies aimed at halting the disease process are needed. One type of immune cell thought to contribute to T1D is the B lymphocyte. The first Phase II trial of B cell depletion in new onset T1D patients indicated that this slowed the destruction of insulin-producing pancreatic beta cells. The mechanistic basis of the beneficial effects remains unclear. Areas covered: Studies of B cell depletion and deficiency in animal models of T1D. How B cells can influence T cell-dependent autoimmune diabetes in animal models. The heterogeneity of B cell populations and current evidence for the potential contribution of specific B cell subsets to diabetes, with emphasis on marginal zone B cells and B1 B cells. Expert opinion: B cells can influence the T cell response to islet antigens and B cell depletion or genetic deficiency is associated with decreased insulitis in animal models. New evidence suggests that B1 cells may contribute to diabetes pathogenesis. A better understanding of the roles of individual B cell subsets in disease will permit fine-tuning of therapeutic strategies to modify these populations.

U2 - 10.1517/14728222.2011.561320

DO - 10.1517/14728222.2011.561320

M3 - Article

C2 - 21366498

VL - 15

SP - 703

EP - 714

JO - Expert Opinion on Therapeutic Targets

JF - Expert Opinion on Therapeutic Targets

SN - 1472-8222

IS - 6

ER -