Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly

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@misc{da7a50b45f1b47d4ba2c2b91b41a8001,
title = "Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly",
abstract = "Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10 million new cases and 1.5 million deaths in 2019. This global emergency is exacerbated by the emergence of multi-drug-resistant MDR-TB and extensively-drug-resistant XDR-TB, therefore new drugs and new drug targets are urgently required. From a whole-cell phenotypic screen a series of azetidines derivatives termed BGAz, that elicit potent bactericidal activity with MIC99 values ",
author = "John Fossey",
year = "2020",
month = sep,
day = "3",
doi = "10.1101/2020.09.03.281170",
language = "English",
type = "Other",

}

RIS

TY - GEN

T1 - Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly

AU - Fossey, John

PY - 2020/9/3

Y1 - 2020/9/3

N2 - Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10 million new cases and 1.5 million deaths in 2019. This global emergency is exacerbated by the emergence of multi-drug-resistant MDR-TB and extensively-drug-resistant XDR-TB, therefore new drugs and new drug targets are urgently required. From a whole-cell phenotypic screen a series of azetidines derivatives termed BGAz, that elicit potent bactericidal activity with MIC99 values

AB - Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10 million new cases and 1.5 million deaths in 2019. This global emergency is exacerbated by the emergence of multi-drug-resistant MDR-TB and extensively-drug-resistant XDR-TB, therefore new drugs and new drug targets are urgently required. From a whole-cell phenotypic screen a series of azetidines derivatives termed BGAz, that elicit potent bactericidal activity with MIC99 values

UR - http://dx.doi.org/10.1101/2020.09.03.281170

U2 - 10.1101/2020.09.03.281170

DO - 10.1101/2020.09.03.281170

M3 - Other contribution

ER -