Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly

Research output: Other contribution

Authors

Colleges, School and Institutes

Abstract

Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10 million new cases and 1.5 million deaths in 2019. This global emergency is exacerbated by the emergence of multi-drug-resistant MDR-TB and extensively-drug-resistant XDR-TB, therefore new drugs and new drug targets are urgently required. From a whole-cell phenotypic screen a series of azetidines derivatives termed BGAz, that elicit potent bactericidal activity with MIC99 values

Details

Original languageEnglish
Publication statusPublished - 3 Sep 2020