Autoimmunity to HSP60 during diet induced obesity in mice

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

External organisations

  • BRISTOL UNIVERSITY
  • Laboratory of Autoimmunity, Division for Experimental Pathology and Immunology, Biocenter Innsbruck Medical University, Innsbruck, Austria.

Abstract

Adaptive immunity has been implicated in adipose tissue inflammation, obesity and its adverse metabolic consequences. No obesity-related autoantigen has yet been identified, although heat shock protein 60 (HSP60) has been implicated in other autoimmune diseases. We investigated whether feeding a high-fat diet to C57BL/6J mice would cause autoimmunity to HSP60 and whether immunomodulation with peptides from HSP60 would reverse the resulting obesity or metabolic dysfunction. Obese mice had higher circulating levels of HSP60 associated with increased T-lymphocyte proliferation responses and the emergence of circulating IgG1 and IgG2c antibody levels against HSP60. Treatment with escalating doses of a mixture of three proven immunomodulatory HSP60 peptides did not reduce weight but completely reversed the increase in VLDL/LDL levels and partially reversed the glucose intolerance in obese mice. Obese mice mount an autoimmune response to HSP60, which partly underlies the resulting metabolic disturbances.

Details

Original languageEnglish
Pages (from-to)348-351
Number of pages4
JournalInternational Journal of Obesity
Volume41
Issue number2
Early online date20 Dec 2016
Publication statusPublished - Feb 2017