Autoimmune hepatitis: new paradigms in the pathogenesis, diagnosis, and management

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Autoimmune hepatitis: new paradigms in the pathogenesis, diagnosis, and management. / Hubscher, Stefan; Oo, Ye Htun; Adams, David.

In: Hepatology International, Vol. 4, No. 2, 01.06.2010, p. 475-493.

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@article{d22463e5dced4d038525740b72007617,
title = "Autoimmune hepatitis: new paradigms in the pathogenesis, diagnosis, and management",
abstract = "Autoimmune hepatitis (AIH), primary biliary cirrhosis, and primary sclerosing cholangitis are the three major autoimmune diseases affecting the liver, and of these three, AIH is the most typical autoimmune disease being characterized by a T-cell-rich infiltrate, raised circulating gamma-globulins, autoantibodies, HLA associations, and links with other autoimmune diseases. It is the only one, of the three diseases, that responds well to immunosuppressive therapy. AIH is caused by dysregulation of immunoregulatory networks and the consequent emergence of autoreactive T cells that orchestrate a progressive destruction of hepatocytes leading untreated to liver failure. T cells play a major role in the immunopathogenesis, and both CD4(+) and CD8(+) T cells are involved together with effector responses mediated by NK cells, gamma delta T cells, and macrophages. A number of triggering factors have been proposed including viruses, xenobiotics, and drugs, but none have been conclusively shown to be involved in pathogenesis.",
keywords = "Recruitment, Mycophenolate mofetil, Autoimmune liver disease, Lymphocytes, Th17, Regulatory T cell",
author = "Stefan Hubscher and Oo, {Ye Htun} and David Adams",
year = "2010",
month = jun,
day = "1",
doi = "10.1007/s12072-010-9183-5",
language = "English",
volume = "4",
pages = "475--493",
journal = "Hepatology International",
issn = "1936-0533",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Autoimmune hepatitis: new paradigms in the pathogenesis, diagnosis, and management

AU - Hubscher, Stefan

AU - Oo, Ye Htun

AU - Adams, David

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Autoimmune hepatitis (AIH), primary biliary cirrhosis, and primary sclerosing cholangitis are the three major autoimmune diseases affecting the liver, and of these three, AIH is the most typical autoimmune disease being characterized by a T-cell-rich infiltrate, raised circulating gamma-globulins, autoantibodies, HLA associations, and links with other autoimmune diseases. It is the only one, of the three diseases, that responds well to immunosuppressive therapy. AIH is caused by dysregulation of immunoregulatory networks and the consequent emergence of autoreactive T cells that orchestrate a progressive destruction of hepatocytes leading untreated to liver failure. T cells play a major role in the immunopathogenesis, and both CD4(+) and CD8(+) T cells are involved together with effector responses mediated by NK cells, gamma delta T cells, and macrophages. A number of triggering factors have been proposed including viruses, xenobiotics, and drugs, but none have been conclusively shown to be involved in pathogenesis.

AB - Autoimmune hepatitis (AIH), primary biliary cirrhosis, and primary sclerosing cholangitis are the three major autoimmune diseases affecting the liver, and of these three, AIH is the most typical autoimmune disease being characterized by a T-cell-rich infiltrate, raised circulating gamma-globulins, autoantibodies, HLA associations, and links with other autoimmune diseases. It is the only one, of the three diseases, that responds well to immunosuppressive therapy. AIH is caused by dysregulation of immunoregulatory networks and the consequent emergence of autoreactive T cells that orchestrate a progressive destruction of hepatocytes leading untreated to liver failure. T cells play a major role in the immunopathogenesis, and both CD4(+) and CD8(+) T cells are involved together with effector responses mediated by NK cells, gamma delta T cells, and macrophages. A number of triggering factors have been proposed including viruses, xenobiotics, and drugs, but none have been conclusively shown to be involved in pathogenesis.

KW - Recruitment

KW - Mycophenolate mofetil

KW - Autoimmune liver disease

KW - Lymphocytes

KW - Th17

KW - Regulatory T cell

U2 - 10.1007/s12072-010-9183-5

DO - 10.1007/s12072-010-9183-5

M3 - Review article

C2 - 20827405

VL - 4

SP - 475

EP - 493

JO - Hepatology International

JF - Hepatology International

SN - 1936-0533

IS - 2

ER -