Autoimmune hepatitis: an approach to disease understanding and management
Research output: Contribution to journal › Article › peer-review
INTRODUCTION: Autoimmune hepatitis is a chronic immune-mediated liver injury, frequently associated with progression to end-stage liver disease if untreated. Patients commonly present with hepatitis, positive immune serology, elevated immunoglobulins and compatible liver histology, in the absence of an alternative aetiology.
SOURCES OF DATA: Data for this review were obtained using PubMed.
AREAS OF AGREEMENT: Disease usually responds to steroids and azathioprine, and appears to be a manifestation of autoimmune predisposition triggered in genetically susceptible individuals exposed to likely environmental challenges. We provide an up-to-date approach to disease understanding and management along with the clinical approach to diagnosis and current treatment suggestions.
AREAS OF CONTROVERSY: Controversies such as second line therapies and novel markers of disease activity are introduced.
GROWING POINTS: Increased understanding of the immunoregulatory mechanisms behind autoimmune hepatitis has led to opportunities for new therapies. These are developed including a discussion of timely research studies relevant to future therapies for patients.
|Number of pages||11|
|Journal||British Medical Bulletin|
|Early online date||20 May 2015|
|Publication status||Published - Jun 2015|