Autoimmune Hepatitis: Tolerogenic Immunological State During Pregnancy and Immune Escape in Post-partum

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Autoimmune Hepatitis : Tolerogenic Immunological State During Pregnancy and Immune Escape in Post-partum. / Bozward, Amber G; Wootton, Grace E; Podstawka, Oskar; Oo, Ye H.

In: Frontiers in immunology, Vol. 11, 591380, 24.09.2020.

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@article{a7a5a08326684ece9011fd6b408e6220,
title = "Autoimmune Hepatitis: Tolerogenic Immunological State During Pregnancy and Immune Escape in Post-partum",
abstract = "The maternal immune system engages in a fine balancing act during pregnancy by simultaneously maintaining immune tolerance to the fetus and immune responses to protect against invading organisms. Pregnancy is an intricately orchestrated process where effector immune cells with fetal specificity are selectively silenced. This requires a sustained immune suppressive state not only by expansion of maternal Foxp3+ regulatory T cells (Tregs) but also by leaning the immune clock toward a Th2 dominant arm. The fetus, known as a semi-allograft or temporary-self, leads to remission of autoimmune hepatitis during pregnancy. However, this tolerogenic immune state reverts back to a Th1 dominant arm, resulting in post-partum flare of AIH. Various hormones play a significant role in endocrine-immune axis during pregnancy. The placenta functions as a barrier between the maternal immune system and the fetus also plays a pivotal role in creating a tolerogenic environment during pregnancy. We review the evidence of immune tolerance during pregnancy and immune escape at post-partum period, focusing on patients with autoimmune hepatitis.",
keywords = "pregnancy, tolerance, autoimmune hepatitis, placenta, memory T cells, regulatory T cells",
author = "Bozward, {Amber G} and Wootton, {Grace E} and Oskar Podstawka and Oo, {Ye H}",
note = "Copyright {\textcopyright} 2020 Bozward, Wootton, Podstawka and Oo.",
year = "2020",
month = sep,
day = "24",
doi = "10.3389/fimmu.2020.591380",
language = "English",
volume = "11",
journal = "Frontiers in immunology",
issn = "1664-3224",
publisher = "Frontiers",

}

RIS

TY - JOUR

T1 - Autoimmune Hepatitis

T2 - Tolerogenic Immunological State During Pregnancy and Immune Escape in Post-partum

AU - Bozward, Amber G

AU - Wootton, Grace E

AU - Podstawka, Oskar

AU - Oo, Ye H

N1 - Copyright © 2020 Bozward, Wootton, Podstawka and Oo.

PY - 2020/9/24

Y1 - 2020/9/24

N2 - The maternal immune system engages in a fine balancing act during pregnancy by simultaneously maintaining immune tolerance to the fetus and immune responses to protect against invading organisms. Pregnancy is an intricately orchestrated process where effector immune cells with fetal specificity are selectively silenced. This requires a sustained immune suppressive state not only by expansion of maternal Foxp3+ regulatory T cells (Tregs) but also by leaning the immune clock toward a Th2 dominant arm. The fetus, known as a semi-allograft or temporary-self, leads to remission of autoimmune hepatitis during pregnancy. However, this tolerogenic immune state reverts back to a Th1 dominant arm, resulting in post-partum flare of AIH. Various hormones play a significant role in endocrine-immune axis during pregnancy. The placenta functions as a barrier between the maternal immune system and the fetus also plays a pivotal role in creating a tolerogenic environment during pregnancy. We review the evidence of immune tolerance during pregnancy and immune escape at post-partum period, focusing on patients with autoimmune hepatitis.

AB - The maternal immune system engages in a fine balancing act during pregnancy by simultaneously maintaining immune tolerance to the fetus and immune responses to protect against invading organisms. Pregnancy is an intricately orchestrated process where effector immune cells with fetal specificity are selectively silenced. This requires a sustained immune suppressive state not only by expansion of maternal Foxp3+ regulatory T cells (Tregs) but also by leaning the immune clock toward a Th2 dominant arm. The fetus, known as a semi-allograft or temporary-self, leads to remission of autoimmune hepatitis during pregnancy. However, this tolerogenic immune state reverts back to a Th1 dominant arm, resulting in post-partum flare of AIH. Various hormones play a significant role in endocrine-immune axis during pregnancy. The placenta functions as a barrier between the maternal immune system and the fetus also plays a pivotal role in creating a tolerogenic environment during pregnancy. We review the evidence of immune tolerance during pregnancy and immune escape at post-partum period, focusing on patients with autoimmune hepatitis.

KW - pregnancy

KW - tolerance

KW - autoimmune hepatitis

KW - placenta

KW - memory T cells

KW - regulatory T cells

U2 - 10.3389/fimmu.2020.591380

DO - 10.3389/fimmu.2020.591380

M3 - Review article

C2 - 33072138

VL - 11

JO - Frontiers in immunology

JF - Frontiers in immunology

SN - 1664-3224

M1 - 591380

ER -